Tumori Journal Abstract Book - October 2020 - 136

136	
with metastatic and locally advanced disease to consider any
or a combination of radiation, surgery, and chemotherapy.
MCC is associated with poor survival outcomes in patients
with metastatic disease. For this setting, results of part A of
the JAVELIN Merkel 200 trial (avelumab in patients with
Merkel cell carcinoma) showed that avelumab, an anti-programmed cell death ligand 1 (PD-L1) antibody, demonstrated
efficacy in second-line or later treatment of patients with
metastatic MCC. So, as we know from the results of recent
scientific literature, avelumab is indicated as monotherapy for
the treatment of adult patients with metastatic MCC.
Methods: In our experience, from march 2019 tojune 2020,
we have treated in first line four patients affected by
advanced MCC (all women; median age, 75 years [range,
65-83 years]), with avelumab ( 10 mg/kg, by 1-hour intravenous infusion every 2 weeks until confirmed disease progression, unacceptable toxic effects, or withdrawal
occurred), with a median follow-up of 8 months (range,
2-12 months). Neither dose reductions nor G3/G4 toxicities
were registered. The most common Grade 2 adverse events
observed until today were fatigue and leukopenia; An objective response was obtained in 3 patients [complete response
in one, partial response in 2, stable disease in the third, progressive disease in one patient]. The median progression
free survival was 12 months. In the case of one patient, we
continued with avelumab beyond cerebral instrumental progression, in consideration of the clinical benefit and the partial response on the other abdominal lymph node target
lesions, with median follow up of 11 months.
Conclusions: In our experience, first-line avelumab treatment was generally well tolerated, and no treatmentrelated deaths or grade 4 adverse events occurred, with
high rates of response. Maturing progression-free survival
data suggest that responses are durable.

G11
RADIOINDUCED SARCOMAS. A
MONOINSTITUTIONAL EXPERIENCE
Bochicchio A.M.1, Omer L.C.1, Ardito R.1, Sgambato A.2, Aieta M.2,
Vita G.1, Patitucci G.1, Fabrizio T.1
1

IRCCS-CROB, Rionero in Vulture; 2IRCCS-CROB, Potenza

Background: The oncologic risk of ionizing radiation is
widely known. Sarcomas developing after radiotherapy as
a "iatrogenic disease of success" have been reported, and
they are a growing problem because rapid advancements
in cancer management and screening have increased the
number of long-term survivors. Although many patients
have undergone radiation treatment, only few data are
available on radio induced sarcomas (RIS).
Material (patients) and methods: We examined the
records of 131 patients with soft tissue sarcomas, confirmed by immunohistochemistry treated in our Centre

Tumori Journal 106(2S)
from 2009 to 2019. Five patients had a histologic diagnose
of secondary RIS, 36 months passed from primary to secondary tumor, consistent with literature data. In our experience, we have observed 3 radio induced sarcoma after
breast cancer, 2 after head and neck cancer (H&N), out of
131 total cases, M/F:59/71, mean age 63, (r:15-91). At present, 63 patients are still in a mean follow-up of 22 months
(range:1-384). The in/out geographic origin is: Basilicata
18/63, Campania 27/63, Puglia 11/63, others 7/63. The
first diagnose was made at CROB for 100/131 patients.
Surgical treatment involved a radical excision in 72
patients, in 56 patients metastases were diagnosed at the
first CT exam, while 42 cases had the mets. during the
follow-up. All patients except one, were treated in our
Centre; 22 patients received external radiotherapy, 1
brachytherapy, 6 elettrochemotherapy (ECT). Out of 72
patients who received chemotherapy, 36 had first line, 30
the second and 5 patients had three lines. In 3 cases
Olaratumab was comprised in the first line treatment, 1
received Crizotinib for a miofibroblastic inflammatory
tumor of a sclero-congiuntive localization with ALK+, 1
with cordoma received Imatinib. Out of the 5 RIS, 1
received radiotherapy, 1 surgery and ECT, 3 had 3 lines of
chemotherapy.
Results: The histology of RIS is: 1 desmoid tumor cervical localized, 1 angiosarcoma, 1 condrosarcoma, 2
leiomiosarcoma.
Conclusions: Radioinduced sarcoma is a possible complication of oncologic long patient survival, requiring attention for an early diagnose and possible new life saving
therapies. Key words: RIS, Head and neck, ECT

H - Genitourinary Tumours
H01
Effectiveness of Abiraterone
Acetate plus Prednisone in
chemotherapy-naïve patients with
metastatic castration-resistant
prostate cancer in a large
prospective real-world cohort:
the ABItude study
Procopio G.1, Chiuri V.E.2, Giordano M.3, Mantini G.4, Maisano R.5,
Bordonaro R.6, Calvani N.7, Facchini G.8, De Placido S.9, Airoldi M.10,
Sbrana A.11, Gasparro D.12, Ludovico G.M.13, Guglielmini P.F.14,
Naglieri E.15, Fagnani D.16, Aglietta M.17, Schips L.18, Sciarra A.19, Livi
L.20, Santini D.21
1
Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale
dei Tumori, Milano; 2Medical Oncology Department, Ospedale Vito Fazzi,
Lecce; 3Medical Oncology Division, ASST-Lariana, Como; 4Radiochemotherapy
Unit, Department of Diagnostics for Imaging, Oncological Radiotherapy and
Hematology, Fondazione Policlinico A. Gemelli IRCCS, Rome - University
Department of Radiological and Hematological Sciences, Università
Cattolica Sacro Cuore, Rome; 5Department of Oncology, A.O. Bianchi-



Tumori Journal Abstract Book - October 2020

Table of Contents for the Digital Edition of Tumori Journal Abstract Book - October 2020

Contents
Tumori Journal Abstract Book - October 2020 - Cover1
Tumori Journal Abstract Book - October 2020 - Cover2
Tumori Journal Abstract Book - October 2020 - I
Tumori Journal Abstract Book - October 2020 - II
Tumori Journal Abstract Book - October 2020 - Contents
Tumori Journal Abstract Book - October 2020 - IV
Tumori Journal Abstract Book - October 2020 - V
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