Tumori Journal Abstract Book - October 2020 - 135

G - Neuroendocrine Tumours and Sarcomas	
(4.2%). No cardiovascular events or severe sepsis were
detected. In 6 (25%) pts CT was delayed due to toxicity. 26
pts were evaluable for response. KS RR and CR were
achieved in 24 (92.3%) and 20 (76.9%) pts respectively.
After a median follow-up of 27 (12, 65) months, no disease related deaths were reported. DP incidence rate was
0.78 (0, 2.31) per 1000 PY.
Conclusions: PLD associated with cART is an effective,
feasible and well-tolerated first-line therapy in advanced
AIDS-KS. We found a RR higher than other previous clinical studies (RR 58.7-84%), probably due to no prior systemic therapy and high percentage of cART-naïve pts.

G09
Evaluation of prognostic role
of inflammatory index in first
line chemotherapy soft tissue
sarcoma patients
Fausti V.1, Foca F.1, Gurrieri L.1, Debonis S.A.1, Bongiovanni A.1, Riva
N.1, De Vita A.1, Mercatali L.1, Ibrahim T.1
1
IRST-Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori,
Meldola, Forlì-Cesena

Background: Soft tissue sarcomas (STS) are rare malignancies with different prognosis and response to therapy.
Hematologic markers of inflammation have been shown to
be prognostic in several malignancies. Aim of the study is
to evaluate retrospectively the prognostic role of these
markers in patients (pts) affected by STS receiving a first
line chemotherapy for metastatic disease.
Methods: Adult pts with STS receivin first line chemotherapy from 2008 to 2019 were selected for this study. Data on
blood counts were carried out the day before starting therapy. Neutrophil and Platelet lymphocyte ratio (NLR and
PLR) were computed as the ratio of the absolute neutrophil
count and absolute platelet count by the absolute lymphocyte count respectively. Systemic Inflammatory Index (SII)
was calculated as platelet count×neutrophil count/lymphocyte count. Overall survival (OS) and Progression-free survival (PFS) using Kaplan-Meier method were stratified
considering different cut off for hematologic markers, found
using X-tile software version 3.6.1.
Results: Ninety-four pts were enrolled. Pts characteristics
are showed in Table 1. Pts with a SII <2693 showed a better OS compared to patients with SII ⩾2693 (15.3 mo Vs
5 mo p- value 0.005); no statistical significant difference
was seen in terms of PFS. Pts with a NLR < 6.7 showed a
better OS and PFS compared to patients with NLR ⩾ 6.7
(OS: 16.1 mo Vs 3 mo p- value <0.001; PFS 5.4 mo VS
2.3 mo p- value 0.010). Pts with a PLR < 85 showed a
better OS compared to patients with PLR ⩾ 85 (33 mo Vs
12.8 mo p- value 0.052); no statistical significant difference was seen in terms of PFS. No statistical significant

135
difference was seen in PFS or OS among different histology or kind of first line treatment.
Conclusions: This retrospective study confirms the prognostic role of inflammatory indices in STS, suggesting that a
systemic inflammatory status is associated with more aggressive and less responsive to standard treatments diseases.
Table 1.  Patients characteristics.
N 94 (%)
Gender
Male
Female
Age at diagnosis
Median (range)
Age at treatment
Median (range)
Surgery at diagnosis
None
Not radical
Radical
Adjuvant therapy
None
CT only
RT only
RT+CT
Histotype
Leiomiosarcoma
Liposarcoma
UPS
Other
First line treatment
Antracycline based
Gemcitabine based
Trabectidine
Other

 
41 (43.6)
53 (56.4)
 
62 (22-84)
 
64 (24-84)
 
31 (33.0)
17 (18.1)
47 (48.9)
 
40 (63.5)
13 (20.6)
9 (14.3)
1 (1.6)
 
29 (30.8)
17 (18.1)
11 (11.7)
37 (39.4)
 
57 (60.7)
14 (14.9)
13 (13.8)
10 (10.6)

G10
Safety and high rates of
response with Avelumab as first
line of treatment in Merkel
Cell carcinoma: a real word
experience
Savastano C.1, Lombardi F.1, Rispoli A.I.1, Fusciello C.1, De Divitiis C.1
1

AOU San Giovanni di Dio e Ruggi D'Aragona, Salerno

Background: Merkel cell carcinoma (MCC) is a rare and
aggressive primary neuroendocrine cutaneous carcinoma of
the skin which can be distinguished from other malignancies
by the expression of cytokeratin 20 (CK20).The National
Comprehensive Cancer Network (NCCN)guidelines recommend multidisciplinary tumor board consultation for patients



Tumori Journal Abstract Book - October 2020

Table of Contents for the Digital Edition of Tumori Journal Abstract Book - October 2020

Contents
Tumori Journal Abstract Book - October 2020 - Cover1
Tumori Journal Abstract Book - October 2020 - Cover2
Tumori Journal Abstract Book - October 2020 - I
Tumori Journal Abstract Book - October 2020 - II
Tumori Journal Abstract Book - October 2020 - Contents
Tumori Journal Abstract Book - October 2020 - IV
Tumori Journal Abstract Book - October 2020 - V
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Tumori Journal Abstract Book - October 2020 - Cover3
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