Tumori Journal Abstract Book - October 2020 - 134

134	
1.14]; p=0.013) and for death (HR: 1.09 [95%CI: 1.011.17]; p=0.023).
Conclusions: Fluoropyrimidine-based regimens with
oxaliplatin (FOLFOX/XELOX) may be active and effective in NET G3 of gastro-entero-pancreatic origin.

G07
DLL3 is expressed in high-grade
gastroenteropancreatic
neuroendocrine neoplasms and
has prognostic significance
Liverani C.1, Bongiovanni A.2, Mercatali L.2, Pieri F.3, Spadazzi C.2,
Miserocchi G.2, Di Menna G.2, Foca F.4, Ravaioli S.5, De Vita A.2,
Aprile M.R.6, Cocchia C.2, Recine F.2, Ibrahim T.2
1

PhD, Meldola; 2Osteoncology and Rare Tumors Center, Istituto Scientifico
Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola;
3
Pathology Unit, Morgagni-Pierantoni Hospital, Forlì, Italy, Forlì; 4Unit of
Biostatistics and Clinical Trials, Istituto Scientifico Romagnolo per lo Studio e
la Cura dei Tumori (IRST) IRCCS, Meldola; 5Biosciences Laboratory, Istituto
Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS,
Meldola; 6e AUSL Romagna, Ospedale Santa Maria delle Croci, Ravenna

Background: Gastroenteropancreatic neuroendocrine
neoplasms (GEP-NENs) are a rare and heterogeneous subgroup of tumors with an extremely variable clinical behaviour and challenging management. A critical need is to
identify molecular diagnostic criteria to discriminates
grade 3 neuroendocrine tumors (NETs) from neuroendocrine carcinomas (NECs). These two entities have a completely different natural history, but their recognition is
based only on the assessment of cell differentiation. The
negative Notch regulator DLL3 is a new therapeutic target
that was found to be highly expressed in certain tumors
with neuroendocrine features.
Methods: A retrospective immunohistochemical analysis
of DLL3, RB1 and PD-L1 expression was performed on
FFPE samples from 43 patients with GEP-NEN and correlated with clinical characteristics and outcome.
Results: DLL3 was found to be expressed only in highgrade (G3) GEP-NEN. Moreover, it was significantly
associated with the presence of poorly differentiated NEC
classification: the 77.8% of NEC patients (7 out of 9) had
a DLL3 positive neoplasia, while none of the 4 patients
with G3 NET showed expression of this marker (p= 0.021).
Expression of DLL3 correlated with loss of RB1 (p<
0.001), negative 68Ga-PET/CT scan (p= 0.001) and unfavourable clinical outcome with implication for patient
treatment and follow-up. Median progression-free survival
(PFS) and overall survival (OS) were, respectively, 41.9
and 72.9 months in patients with a DLL3-negative neoplasia versus 7.9 and 11.7 months in DLL3-positive patients
(p= 0.0054 for PFS and p= 0.0036 for OS) .
Conclusions: DLL3 might represent an objective histological marker to be combined with cell morphological

Tumori Journal 106(2S)
analysis for the diagnosis of poorly differentiated NEC.
The high percentage of DLL3 expression in NEC patients
also indicates a potential opportunity for a DLL3 targeted
therapy in this subset.

G08
PEGYLATED LIPOSOMAL DOXORUBICIN
(PLD) IS AN EFFECTIVE FIRST LINE
TREATMENT IN AIDS-RELATED KAPOSI'S
SARCOMA (AIDS-KS) IN COMBINATION
ANTIRETROVIRAL THERAPY (cART)
NAIVE PATIENTS
Dalu D.1, Ammoni L.1, De Francesco D.2, Cona M.S.1, Fasola C.1,
Foschi A.3, Filipazzi V.1, Rota S.1, La Verde N.1
1

ASST Fatebenefratelli Sacco - Polo Ospedaliero Luigi Sacco - Department
of Oncology, Milan; 2UCL - Institute for Global Health - London, London;
3
ASST Fatebenefratelli Sacco - Polo Ospedaliero Luigi Sacco - Department of
Infectious Disease, Milan

Background: The widespread introduction of effective
cART has had a major influence on the epidemiology of
AIDS-associated cancer. Nevertheless AIDS-KS remains
the most common malignancy among people living with
HIV (12-20%). In advanced stage or progressive forms
chemotherapy (CT) in combination with cART is the treatment of choice. The aim of the study is to evaluate efficacy
and tolerability of PLD as first line CT in AIDS-KS.
Materials and Methods: This is a single institution retrospective study conducted in ASST Fatebenefratelli Sacco,
PO Luigi Sacco (Milan, Italy). We selected HIV+ patients
(pts) with KS from March 2009 to March 2019. cART was
continued during CT. AIDS-KS pts were staged according
to AIDS Clinical Trials Group Oncology Committee. CT
was administered in poor risk and some cases of good
prognosis/limited cutaneous disease. Treatment plan: PLD
20 mg/m2 IV every 2 weeks for 6 to 12 cycles. Efficacy of
CT was evaluated as response rate (RR) = complete
response (CR) + partial response (PR) and disease progression (DP) from the beginning of CT. CR was defined
as total regression of complications, smoothing of all
lesions, only pigmented inactive patches remaining.
Adverse events were evaluated according to CTCAE v5.0.
Results: We enrolled 33 pts with AIDS-KS: median age at
KS diagnosis 44ys (37, 49), male 90.9%, Caucasian 72.7%,
cART-naïve (simultaneous diagnosis of HIV infection and
KS) 84.4%, median lymphocyte CD4+ count 134 cells/µL
(43, 288), median HIV viral load 4.9 log10 copies/ml (4.5,
5.6). KS stage was classified as Poor Risk in 32 (97%) pts.
In 2 (6.1%) pts disease was limited to skin. A median of 6
cycles (range 6-12) of PLD were administered. During CT,
grade 3-4 toxicity was observed in 8 (33.3%) pts: neutropenia 3 (12.5%), thrombocytopenia 2 (8.3%), hand-foot
skin syndrome 2 (8.3%), infections 2 (8.3%), anemia 1



Tumori Journal Abstract Book - October 2020

Table of Contents for the Digital Edition of Tumori Journal Abstract Book - October 2020

Contents
Tumori Journal Abstract Book - October 2020 - Cover1
Tumori Journal Abstract Book - October 2020 - Cover2
Tumori Journal Abstract Book - October 2020 - I
Tumori Journal Abstract Book - October 2020 - II
Tumori Journal Abstract Book - October 2020 - Contents
Tumori Journal Abstract Book - October 2020 - IV
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