Tumori Journal Abstract Book - October 2020 - 130

130	
Results: Overall, 148 (66.1%) patients had a FIGO stage III
and 29 (13%) a FIGO stage IV; residual disease was present
in 93 (42.1%) patients after radical surgery. A total of 70
(30.8%) patients experienced haematologic toxicity, 51
(24.1%) with carboplatin dose reduction, among which 22
(43.1%) for CIT. Median OS was 74.6 months and known
prognostic factors for a lower OS, such as residual tumor
after radical surgery (HR 2.15, p = 0.031) and FIGO stage
IV (HR 4.82, p = 0.008), were confirmed by uni-/multivariate analysis. Platelets count (PLT) (OR 0.99, CI 95% 0.980.99, p = 0.009) and weight (OR 1.04, CI 95% 1.01-1.07, p
= 0.016) at baseline were significantly associated with CIT.
After ROC-defined cut-off definition, PLT and weight were
both statistically significant at multivariate analysis with a
cut-off value of 295.000/μL (OR 0.13, p < 0.001) and 79.4
kg (OR 4.86, p = 0.006), respectively. A score combining
PLT < 295.000/µL and weight > 79.4 kg was implemented
and was able to stratify the study population into low, intermediate and high risk groups according to CIT (OR 5.38, p
= 0.005 with one of the two conditions, OR 39.75, p <
0.001 with both conditions).
Conclusions: In patients with ovarian cancer receiving a
carboplatin-based adjuvant therapy, platelets count and
weight at baseline are two easy-to-assess parameters to
predict CIT risk. Prospective validation is planned to prove
the clinical efficacy and utility of the present score.

F06
Bevacizumab and ovarian cancer:
a matter of pharmacokinetics
Fiordoliva I.1, Maccaroni E.1, Giampieri R.1, Agostinelli V.1, Tronconi
F.1, Zepponi L.1, Bianchi F.1, Pagliacci A.1, Pistelli M.1, Savini A.1,
Belvederesi L.1, Pagliaretta S.1, Brugiati C.1, Murrone A.1, Berardi R.1
1
Clinica Oncologica-Universita' Politecnica Delle Marche-Ospedali Riuniti di
Ancona, Ancona

Background: Bevacizumab is a humanized monoclonal
antibody against vascular endothelial growth factor and is
used as both first- and second-line treatment in combination with standard chemotherapy and subsequent maintenance for FIGO stage IIIB-IV ovarian cancer (OC). FIGO
stage, residual disease after surgery or lack of surgery altogether are prognostic factors in this setting. Aim of the
study is to assess whether estimates in Bevacizumab pharmacokinetics might have an impact on patients' survival.
Materials and methods: We retrospectively enrolled OC
patients treated between May 2015 and May 2020 at our institution. Clinico-pathological data and blood tests results of OC
patients treated with bevacizumab were collected. Volume of
distribution (VD, mL) and clearance (CL, mL/h) were calculated using body weight, albumin and alkaline phosphatase at
baseline, as previously published. Bevacizumab time to elimination (TTE) was calculated as [VD/CL] and expressed in
days. Cut-off values for all tests were set by using median

Tumori Journal 106(2S)
values of VD, CL and TTE. Kaplan-Meier method was used
to calculate Progression-Free Survival (PFS). Level of statistical significance of all tests was set at 0.05.
Results: Thirty-two first-line patients were enrolled; median
age was 59.6 years (range 32-80). Most frequent histology
was high-grade serous OC (88%). Most patients had stage
IIIB-IIIC (81%) disease. Median VD was 2461.35 mL,
median CL was 7.88 mL/h and median TTE was 13.14 days.
At the time of analysis, 53% (17/32) patients had already
progressed to bevacizumab. Low vs high bevacizumab VD
was not associated with significantly different PFS
(p=0.4118). Low vs high bevacizumab CL was also not
associated with statistically significant differences in PFS
(p=0.7045). TTE was associated with statistically significant differences in PFS: in patients with greater TTE median
PFS was 23.34 vs 12.86 months of patients with shorter
TTE (HR:2.92, 95%CI:1.05-8.11, p=0.0391). Residual disease after surgery, histology, age, BRCA status were not
associated with differences in PFS also.
Conclusions: Our study suggests that Bevacizumab pharmacokinetics could determine differences in first-line
treatment PFS in OC patients treated with this drug. We
intend to enlarge our patients' series to better estimate the
role of bevacizumab pharmacokinetics in this setting.

G - Neuroendocrine Tumours and
Sarcomas
G01
Temozolomide Alone or
Combined with Capecitabine for
the Treatment of Metastatic
Neuroendocrine Neoplasia: a "Real
World" data analysis
Bongiovanni A.1, Liverani C.1, Foca F.2, Fausti V.1, Signoretti M.3, Pieri
F.4, Tartaglia A.5, Galassi R.6, Cavaliere D.7, Severi S.8, Di Menna G.9,
Mercatali L.9, De Vita A.9, Riva N.9, Calpona S.10, Miserocchi G.10,
Spadazzi C.10, Gurrieri L.10, De Bonis S.A.10, Ibrahim T.10
1

Centro di Osteoncologia e Tumori Rari, Istituto Scientifico Romagnolo per
lo Studio e la cura dei Tumori IRST, IRCCS, Meldola; 2Unità di Biostatistica,
Istituto Scientifico Romagnolo per lo Studio e la cura dei Tumori IRST,
IRCCS, Meldola; 3U.O. di Gastroenterologia/Endoscopia digestiva, Ospedale
G.B. Morgagni-L.Pierantoni, AUSL Romagna, Forlì; 4U.O. di Anatomia
Patologica Ospedale G.B.Morgagni-L.Pierantoni, AUSL Romagna, Forlì; 5U.O.
di Endocrinologia Ospedale G.B. Morgagni-L. Pierantoni, AUSL Romagna,
Forlì.; 6U.O. di Medicina Nucleare Ospedale G.B. Morgagni-L. Pierantoni,
AUSL Romagna, Forlì; 7UO di Chirurgia Generale e Terapie Oncologiche
Avanzate, Ospedale G.B. Morgagni-L. Pierantoni, AUSL Romagna, Forlì;
8
UO di Medicina Nucleare, Istituto Scientifico Romagnolo per lo Studio e la
cura dei Tumori IRST, IRCCS, Meldola; 9Centro di Osteoncologia e Tumori
Rari, Istituto Scientifico Romagnolo per lo Studio e la cura dei Tumori IRST,
IRCCS, Meldola; 10Centro di Osteoncologia e Tumori Rari, Istituto Scientifico
Romagnolo per lo Studio e la Cura dei Tumori IRST, IRCCS, Meldola

Background: Neuroendocrine Neoplasia (NEN) are rare
and groups tumors with different prognosis and response



Tumori Journal Abstract Book - October 2020

Table of Contents for the Digital Edition of Tumori Journal Abstract Book - October 2020

Contents
Tumori Journal Abstract Book - October 2020 - Cover1
Tumori Journal Abstract Book - October 2020 - Cover2
Tumori Journal Abstract Book - October 2020 - I
Tumori Journal Abstract Book - October 2020 - II
Tumori Journal Abstract Book - October 2020 - Contents
Tumori Journal Abstract Book - October 2020 - IV
Tumori Journal Abstract Book - October 2020 - V
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