Tumori Journal Abstract Book - October 2020 - 126

126	
Results: At the present analysis, in a case study of 269
patients within our institution who performed biopsy or surgery, 77 patients were enrolled. The median age was 64.9
(range 34-87). 52 (67.5%) were luminal A, 21% (27.3) luminal B, 4 (5.2% ) triple negative. 44 were in Stage I ( 57.1%),
28 in Stage II ( 36.4%), 3 in Stage III (3.9%), 2 in Stage IV
(2.6%). 6 patients (7.8%) received neoadjuvant treatment, 2
patients (2.6%) received first line treatment for metastatic
disease, 7 patients (7.9%) received adjuvant treatment with
chemotherapy, 9 patients (11.6%) 12 patients ( 15.6%)
received an adjuvant hormonal therapy with tamoxifene and
43 patients ( 55.8%) with aromatase inhibitors.
Conclusions: The data suggest the extreme heterogeneity
of breast cancer and how therapeutic decisions are conditioned by the main histopathological and clinical factors.
New studies on cancer biology HER 2 low and the benefit
of new anti HER 2 drugs are needed to implement diagnostic and therapeutic algorithm.

E51
BREAST CANCER : TIME BETWEEN
ACCESS TO RECEPTION SERVICE
CENTRE (CAS), INTERDISCIPLINAR TEAM
(GIC) VISIT IN A SPOKE HOSPITAL OF
PIEDMONT ONCOLOGY NETWORK (ROP)
Lattuada S.1, Fora G.1, Gasparre T.1, Torazzo R.1, Manachino D.1,
Posca T.1, Zecchin D.1, De Marino E.1
1

Sant'Andrea Hospital, Vercelli

Background: Delay of therapies in oncology is one of
prognostic factors determining the outcome. The Piedmont
oncological network has proposed a new organisational
model by setting the timing between visits cas and gic;
these are affected by the mode of onset of neoplasia.
Objective of the study is to assess the adherence to the
indications of the rop and the interval between cas gic and
surgery for breast cancer in the hospital spoke with the
purpose to define classes of priorities for intervention.
Materials and Methods: The time between the cas visit
and the gic visit was assessed in the light of the reports
prepared by the service reception center.
Results: From January to December 2019, 740 patients for
suspected cancer were visited. 104/740 (14%) visits were
for suspected breast cancer. 99/104 (95%) visits confirmed
breast cancer. cas and gic visits were performed for 37/104
(36%) patients. the waiting time of 24 days between the
cas visit and the gic visit indicated by the oncological network of piedmont was respected for 21/37 (57%) patients.
for 14/37 (38%) patients gic was performed after 24 days.
for 2/37 (5%) the gic was discussed before the cas.
Conclusions: In consideration of the times indicated by
the Piedmontese regional guidelines, the review of the
clinical cases of the Sant'Andrea Hospital of Vercelli

Tumori Journal 106(2S)
shows that for more than 50% of our patients the 24-day
time between cas and gic has been respected.

E52
Genetic susceptibility of breast
and ovarian cancer in Sardinian
population
Palomba G.1, Palmieri G.2, Cossu A.3, Paliogiannis P.3, Pisano M.2,
Manca A.2, Casula M.1, Colombino M.1, Rozzo C.2, Sini M.C.1
1

ICB-CNR, Sassari; 2IRGB-CNR, Sassari; 3AOU, Sassari

Patients who carry a high-risk mutation in one or both of the
BRCA genes (BRCA1 or BRCA2) have a significantly
increased risk of developing breast/ovarian cancer (BOC) and
other cancers (eg, prostate cancer in male). Epidemiological
data on incidence distribution of breast/ovarian cancer from
2016 at 2019 in North Sardinia are obtained from the local
tumor registry and from the cumulative results of 209 genetic
testing for BRCA gene mutations performed to all young
breast cancer patients and all women (over 50 years) with
family history of BOC (total of 164 cases); further 45 genetic
testing are performed, on ovarian cancer patients, at any age.
The results provide a different distribution of fraction mutations carrying by women and a higher prevalence of the brca2
mutation in the north of Sardinia than the entire population
and highlight the presence of specific germline mutation
associated with the "founder effect" in distinct genetic subgroups reflecting genetic drift. With advances in genome
sequencing technology and reductions in the cost of nextgeneration sequencing, molecular profiling has become more
accessible for clinical investigation and cancer research and
allow to characterize those individuals who are potential targets for BRCA molecular-based therapeutics agents.

E53
Real life incidence of adverse
events (AEs) in patients affected
with ER-positive, HER2-negative
advanced breast cancer treated
with Palbociclib: a single
institution experience
Bolzacchini E.1, Pugliese P.1, Marussi D.1, Epifani R.1, Luchena G.1,
Bianchi R.1, Gini G.1, Gilardoni M.1, Giordano M.1
1

ASST-Lariana, Como

Background: Palbociclib in an oral inhibitor of cyclinedependent kinase 4/6, approved based on results of
PALOMA trials for the treatment of ER-positive,HER-2
negative locally advanced or metastatic breast cancer(mBC)
in combination with endocrine therapy(ET).



Tumori Journal Abstract Book - October 2020

Table of Contents for the Digital Edition of Tumori Journal Abstract Book - October 2020

Contents
Tumori Journal Abstract Book - October 2020 - Cover1
Tumori Journal Abstract Book - October 2020 - Cover2
Tumori Journal Abstract Book - October 2020 - I
Tumori Journal Abstract Book - October 2020 - II
Tumori Journal Abstract Book - October 2020 - Contents
Tumori Journal Abstract Book - October 2020 - IV
Tumori Journal Abstract Book - October 2020 - V
Tumori Journal Abstract Book - October 2020 - 1
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