Tumori Journal Abstract Book - October 2020 - 124

124	
Breast cancer (BC) is the most common cancer among
women. The diagnosis and treatments of BC negatively
affect quality of life (QoL) and sexual functioning (SF).
Cancer treatments, including surgery, chemotherapy, radiotherapy and hormone therapy, can directly affect body image,
disrupt relationship closeness and sexuality. The beauty of
the breast is an important aspect to femininity, self estimate
and self confidence in women. Sexuality appear less important than the short and long-term adverse effects of treatment
in cancer patients. Sexual Dysfunction is when at least one
aspect of sexual response cycle does not function properly. It
may be libido, arousal or orgasm that is involved.
Purpose: The purpose of the present study was to assess to
determine the QoL levels of patients with BC during
chemotherapy (A) and follow-up (B) and to find out the
problems that affect their QoL and SF.
Methods: The data were collected using the '36-Item
Short Form Health Survey' (SF-36), a set of generic,
coherent, and easily administered quality-of-life measures
and the 'Female Sexual Function Index' (FSFI) a multidimensional scale for assessment of sexual functioning.
Results: Overall QOL for this sample (N=60) was moderate and treatment procedures caused important problems
that had a negative effect on physical, psychological,
social aspects of QoL. In addition, the main causes of sexual dysfunctions were in group A lack of arousal (2.33) and
lubrification (2.42) while in group B lack of sexual desire
(2.62) and arousal (2.35). The real impact of psychological
aspects of therapy on female sexual functions should be
prospectively studied.
Conclusions: Evaluation of the above variables in BC
women is actually the only way to allow them to face a
relevant aspect of their QoL, most of the times neglected
both by health professionals and themselves too.
Importance of data will suggest hospital institutions to
consider sexual it as a key point in cancer rehabilitation.

Tumori Journal 106(2S)
endocrine therapy), the disturbances of body image, and
mental health problems such as anxiety and depression
could influence sexuality. Very often the aspect of sexuality
in BC is likely not to be fully investigated: cultural barriers
may also contribute to lack of attention to these issues. In
Italy, there are very few Breast Units that provide the figure
of the sexologist. The aim of our study was to evaluate
the influence and changes of BC on the bodily image and
sexuality.
Patients and methods: We enrolled 54 BC pts, mean age
was 54 years. 40 pts (74%) had undergone surgical intervention. Participants were invited to complete a structured
questionnaire, which included four close-up questions
regarding self-image, sexual activity, sexual satisfaction,
analyzing these aspects before and after BC and its treatments. Finally the participants were asked if they needed
the sexologist.
Results: Only 3/54 pts (5.5%) refused to participate in our
study. Of 51 participants, 44 (86.3%) reported that sexuality was an important or a very important aspect in their
lives, while only 7 pts (13.7%) considered it as an unimportant aspect. 22 pts (43.13%) had disturbances of body
image, 24 (47%) had sexuality greatly affected, and 36
(70.5%) sexual dissatisfaction after BC. 17 pts (33.3%)
would require the help of the sexologist.
Conclusions: Our results suggest that despite the significant changes and negative influence in their sexuality, few
pts require the help of the sexologist. Further studies will
be needed to understand the reasons for this disparity.

E48

E47

WHAT IS THE BEST THERAPEUTIC
SEQUENCE FOR ER-POSITIVE/HER2NEGATIVE METASTATIC BREAST
CANCER IN THE ERA OF CDK4/6
INHIBITORS? A SINGLE CENTER
EXPERIENCE

What hides beneath the scar:
sexuality and breast cancer
what women don't say

Crocetti S.1, Pistelli M.1, Tassone L.1, Marcantognini G.1, Bastianelli
L.1, Della Mora A.2, Merloni F.1, Cantini L.1, Scortichini L.1, Agostinelli
V.1, Ballatore Z.1, Savini A.1, Maccaroni E.1, Berardi R.1

La Manna A.1, Gozzi E.2, Rossi L.2, Angelini F.3, Raimondi L.2, Bitca
V.2, Regini D.4, Cimino G.5, Tomao S.6, Calogero A.1, Fontana A.1, De
Masi C.1, Busco S.1, Fara M.A.1, Dorkin M.1, Di Filippo S.1, Ulgiati
M.A.1, Tarallo M.1, Tozzi R.1, Ricci F.1

1
Clinica Oncologica e Centro Regionale di Genetica Oncologica, Università
Politecnica delle Marche, AOU Ospedali Riuniti, Ancona; 2UO Oncologia di
Macerata, Area Vasta 3, Macerata

1

Ospedale Santa Maria Goretti, Latina; 2Università la Sapienza di Roma,
Aprilia; 3Ospedale Regina Apostolorum Albano laziale, Albano; 4Università
la Sapienza di Roma, Albano; 5Università la Sapienza di Roma, Latina;
6
Università la Sapienza di Roma, Roma

Background: Breast is a symbol of femininity, motherhood
and sexuality. Breast cancer (BC) is the most frequent
cancer in Italy: in 2019, 53.500 new cases were diagnosed.
BC and its treatment (surgery, radiation, chemotherapy and

Background: Endocrine therapy has historically formed
the basis of treatment for ER+/HER2- metastatic breast
cancer (MBC). The development of endocrine resistance
has led to the development of newer endocrine drug combinations. Use of CDK4/6 inhibitors (CDK4/6i) has significantly improved progression-free survival in this group
of patients. There are many options in the sequencing of
therapy for ER+ MBC in post-menopausal women. In this
retrospective analysis, we evaluated the sequencing of



Tumori Journal Abstract Book - October 2020

Table of Contents for the Digital Edition of Tumori Journal Abstract Book - October 2020

Contents
Tumori Journal Abstract Book - October 2020 - Cover1
Tumori Journal Abstract Book - October 2020 - Cover2
Tumori Journal Abstract Book - October 2020 - I
Tumori Journal Abstract Book - October 2020 - II
Tumori Journal Abstract Book - October 2020 - Contents
Tumori Journal Abstract Book - October 2020 - IV
Tumori Journal Abstract Book - October 2020 - V
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