Tumori Journal Abstract Book - October 2020 - 122

122	
Material and Methods: A retrospective analysis including MBC pts undergone LM after Tumor Board discussion
at hepatobiliary surgery unit of Fondazione Policlinico
Universitario Agostino Gemelli-IRCCS between January
1994 and December 2019 was conducted. Theprimary
endpoint was overall survival (OS) after MBC-LM; secondary endpoint was diseasefree interval (DFI) after surgery. An exploratory analysis was performed to evaluate
the impact of immunophenotype and others clinical factors
(age, menopausal status, number of metastatic sites, synchronous or metachronous disease, prior systemic therapy
and tumor free resection margin).
Results: Forty-nine MBC pts underwent LM. Clinical data
were available for 22 pts. After a median follow-up of 71
months (m), median OS and DFI were 67m (95%CI
45-103) and 15m (95%CI 11-46), respectively. The histotype was ductal carcinoma for 21 pts, only 1 was lobular;
14 pts had a luminal tumor, 5 pts were triple negative
(TNBC) and 3 pts were HER2+. At univariate analysis,
the presence of a negative resection margin was the only
factor which statistically significantly influenced OS (78
vs 16m; HR 0.083,p< 0.0001) and DFI (16 vs 5m; HR
0.17, p=0.0058). None of the other factors were significantly associated with OS and DFI. An interesting trend
toward significance was observed in OS analysis for menopausal status (pre- vs post-, 50 vs 78 m, p 0.56), metastatic sites (only liver vs other sites, 103 vs 50m, p=0.14)
and prior systemic therapy (none vs >1-line, 50 vs 78m,
p=0.89).
Conclusions: Resection of breast cancer liver metastasis
might represent a therapeutic option for selected pts. The
radical nature of the surgical procedure performed in a
high-flow center and after a multidisciplinary discussion
appears essential for this therapeutic option.

E43
Metastatic HER2-positive breast
cancer: does the benefit of firstline pertuzumab extend over time?
Cantini L.1, Merloni F.1, Pistelli M.1, Crocetti S.1, Bastianelli L.1, Della
Mora A.2, Scortichini L.1, Tassone L.1, Ranallo N.1, Agostinelli V.1,
Ballatore Z.1, Savini A.1, Berardi R.1
1
Clinica Oncologica - Università Politecnica delle Marche - Ospedali Riuniti
Ancona, Ancona; 2UO Oncologia Macerata, Ancona

Background: In metastatic human epidermal growth factor
receptor 2 (HER2)-positive breast cancer (BC), dual HER2
blockade with pertuzumab and trastuzumab plus taxane
(PHT) represents the standard 1st line treatment. In HER2negative hormone receptor (HR)-positive BC, the cyclindependent kinases (CDK) 4/6 inhibitors have proven to
extend their benefit over the subsequent therapy lines.
Conversely, the potential influence of anti-HER2 treatments

Tumori Journal 106(2S)
on subsequent therapy lines outcome has been scarcely
investigated. Aims of our study were to describe our institution experience in the treatment of metastatic HER2-positive
breast cancer and to investigate the prognostic influence of
pertuzumab on subsequent therapy lines.
Patients and methods: We retrospectively analyzed data of
consecutive patients treated for metastatic HER-2 positive
BC between 2004 and 2020. Patients receiving pertuzumab
as 1st line treatment were compared with those who did not.
Median overall survival (mOS) and progression-free survival (mPFS) were estimated using Kaplan-Meier method
and strata were taken into account by long-rank test.
Results: A total of 78 patients were enrolled: median age
at diagnosis was 53 years, 45 HER2 patients (58%) were
also HR-positive, 50% were relapsed patients; 22%
patients were previously treated with trastuzumab in the
adjuvant setting; 29% of patients were treated beyond 3rd
line. mOS from starting of 1st line treatment was 54.3
months. In 1st therapy line (mPFS 19.9 months) 29 patients
(37%) patients were treated with PHT and 21 patients
(27%) with trastuzumab and vinorelbine; other therapeutic
combinations were less represented. In 2nd line (mPFS 8.2
months) the most represented therapeutic agent was
TDM-1 (36%) and 24% of patients were treated with
capecitabine plus lapatinib. In 3rd line (mPFS 8.3 months)
therapeutic decision was balanced between different combinations. Patients treated with pertuzumab had better PFS
in 1st line (mPFS 31.5 vs 15.2 months, HR 1,89, 95%CI
1.07-3.20, p=0.02) but this benefit was lost for PFS in 2nd
(mPFS 5.6 vs 9.5 months, p=0.31) and 3rd (mPFS 4.2 vs
8.3 months, p= 0.30) lines.
Conclusions: In our experience PHT and TDM-1 were the
most represented therapy choices in 1st and 2nd lines,
respectively. 3rd line treatment was more heterogeneous.
Unlike CDK 4/6 or programmed death-(ligand) 1 (PD(L)1) inhibitors, the use of pertuzumab in HER2-positive
BC seems not capable to extend its benefit over subsequent therapy lines.

E44
Collaboration activities of
Genetic Counselling Oncology
and Breast Unit in ASST-Mantova
Adami F.1, Panizza E.1, Carbonardi F.1, Carra S.2, Pisanelli M.B.1,
Rinaldi R.3, Busani M.4
1

ASST "Carlo Poma" S.C. Oncologia, Mantova; 2ASST "Carlo Poma" Screening
Mammografico, Mantova; 3ASST "Carlo Poma" Anatomia Patologica,
Mantova; 4ASST "Carlo Poma" Chirurgia senologica, Mantova

Background: BRCA-mutation carriers have a lifetime
risk of breast cancer that ranges between 36 to 90%.
Bilateral prophylactic mastectomy were both associated
with a decreased breast cancer risk in BRCA1/2 mutation



Tumori Journal Abstract Book - October 2020

Table of Contents for the Digital Edition of Tumori Journal Abstract Book - October 2020

Contents
Tumori Journal Abstract Book - October 2020 - Cover1
Tumori Journal Abstract Book - October 2020 - Cover2
Tumori Journal Abstract Book - October 2020 - I
Tumori Journal Abstract Book - October 2020 - II
Tumori Journal Abstract Book - October 2020 - Contents
Tumori Journal Abstract Book - October 2020 - IV
Tumori Journal Abstract Book - October 2020 - V
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