Tumori Journal Abstract Book - October 2020 - 121

E - Breast Cancer	
rate, and correlation between T-DM1 efficacy and IHC status(3+ vs 2+/FISH+).In total, 74 pts received T-DM1:
Cohort T n=34 (all females, median age=52,7), Cohort PT
n=40 (39 females, 1 male, median age=52,2). Within Cohort
T 64,7% of pts (n=22) received T-DM1 after 1 previous
T-combined regimen, 20,6% (n=7) and 14,7% (n=5) in third
and fourth lines, respectively. Instead, the whole Cohort PT
received T-DM1 after a first-line dual blockade PT.
Results: We found 10,2 months as mPFS for the Cohort T.
Whereas, the Cohort PT mPFS was equal to 3,7 (range: 1,4
- 26,2 m). As regards the best response rate, 8,8% (n=3/34)
and 52,5% (n=21/40) of pts reported a progressive disease
(PD) into the Cohorts T and PT, respectively; stable disease (SD) 38,2%(n=13/34) versus 15% (n=6/40); partial
response (PR) 23,5% (n=8/34) vs 15% (n=6/40); complete
response (CR) 23,5% (n=8/34) vs 12,5% (n=5/40). Almost
2/3 (n=21/34) of Cohort T and half (n=20/40) of Cohort PT
pts had a 3+ IHC status.
Conclusions: Our results show a lower efficacy of T-DM1
after progression on dual HER2-blockade PT. Probably,
the dual blockade PT-induced HER2 extracellular-domain
downregulation makes cells resistant to T-DM1, which
binds to HER2 external portion too. Our analysis does not
take over a significant correlation between IHC status and
T-DM1 efficacy, especially in the Cohort PT. Obviously,
larger prospective studies are necessary in order to optimize the best sequence strategy in the treatment of metastatic HER2+ BC.

E41
Triple Negative Breast Cancer
(TNBC): cases analysis in our
multidisciplinary Breast Unit with
median follow-up of 58.8 months
Rodà G.1, Basilico V.1, Di Cesare P.1, Galeassi A.1, Carnaghi C.2,
Andreoli C.1, Branchini L.1, Arlant V.1, Bossi P.3, Crespi L.1, Formenti
S.1, Zuliani W.1
1

Humanitas Mater Domini, Castellanza; 2Ospedale Provinciale San Maurizio,
Bolzano; 3Istituto Clinico Humanitas, Rozzano

Background: TNBC accounts for approximately 10-15%
of breast cancers diagnosed worldwide.TNBCs are biologically aggressive with poor prognosis.This is due to two
factors:shortened disease-free interval in the adjuvant and
neoadjuvant setting and a more aggressive clinical course in
the metastatic setting. Despite this, the schedule for followup care for TNBC is the same as it is for other types of BC.
Material and methods: From 01.01.2011 to 31.12.2015
in our Breast Unit 1158 cases of BC were treated, 96 of
which were TN (8.3%). Median age of the TN patients
(pts) was 56.3 years (range 31 - 87). 41% of pts were in
premenopausal status. A total of 66 quadrantectomies and
30 mastectomies were performed. Axillary staging was

121
performed with sentinel lymph node biopsy in 86 cases,
resulting positive in 20 (23%) pts who have undergone
axillary dissection. Of the 66 conservatively treated pts, 54
(81.8%) completed local treatment with radiotherapy on
the residual breast. In 71 pts adj treatment was planned, 5
received neo-adj therapy. The schedule used was in all
cases: ACx4 followed by Paclitaxel x 12 weeks. Currently
most pts would have received neoadjuvant treatment.
Results: 4 of the 96 pts were subsequently followed elsewhere after surgery and are therefore excluded from the
present analysis. All other 92 pts have been regularly followed in our Unit for at least 5 years. The median follow-up
is 58.8 months (range 48 - 96). At 31.12.2019 there were a
total of adverse events in 29 cases: distant recurrence 22,
local recurrence 4, controlateral BC 2, axillary lymph node
recurrence 1. Medium interval in months between surgery
and disease recurrence was 26.2 (range 3.8-61.5). Ki67
index was high in most cases (>20% in 90% of pts) and in
particular in pts with disease recurrence(> 20% in 28/29
pts). The current status of the pts at 31.12.2019 is: living
NED 60; living after local recurrence 4; living after controlateral BC 2; living after distant recurrence 9; died from BC
13; died from another cause 4; lost at follow-up 4.
Conclusions: Data analysis shows that TNBC pts, in addition to often having a high Ki67 index, have a disease
recurrence after an average of 2 years. This suggests that a
systematically more intensive follow-up in this setting
should be implemented even if the relationship between
earlier diagnosis of recurrence, more timely and novel
treatments, correlation with biomarker (BRCA and others)
and improvement of overall survival is to be verified more.

E42
Retrospective analysis on
survival impact of liver
metastasectomy (LM) in patients
(pts) with metastatic breast
cancer (MBC)
Pontolillo L.1, Orlandi A.1, Mele C.2, Pasqualoni M.1, Pannunzio S.1,
Cutigni C.1, Garufi G.1, Indellicati G.1, Vellone M.2, Palazzo A.1,
Cassano A.1, Giuliante F.2, Bria E.1, Tortora G.1
1
Oncologia Medica, Comprehensive Cancer Center, Fondazione Policlinico
Universitario Agostino Gemelli-IRCSS, Università Cattolica Del Sacro Cuore,
Roma; 2Comprehensive Cancer Center, Fondazione Policlinico Universitario
Agostino Gemelli-IRCSS, Università Cattolica Del Sacro Cuore, Roma

Background: Liver represents the first metastatic site in
5-12% of MBC. While current evidence support LM for
advanced colorectal cancer in improving survival, on the
basis that hepatic parenchyma filters circulating tumor cells
(CTC) from primary to systemic circulation, MBC-LM is
considered a possible therapeutic option for selected MBC
pts in clinical practice, in absence of reliable evidence.



Tumori Journal Abstract Book - October 2020

Table of Contents for the Digital Edition of Tumori Journal Abstract Book - October 2020

Contents
Tumori Journal Abstract Book - October 2020 - Cover1
Tumori Journal Abstract Book - October 2020 - Cover2
Tumori Journal Abstract Book - October 2020 - I
Tumori Journal Abstract Book - October 2020 - II
Tumori Journal Abstract Book - October 2020 - Contents
Tumori Journal Abstract Book - October 2020 - IV
Tumori Journal Abstract Book - October 2020 - V
Tumori Journal Abstract Book - October 2020 - 1
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Tumori Journal Abstract Book - October 2020 - Cover3
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