Tumori Journal Abstract Book - October 2020 - 120

120	
mutations vs. none (Ki67%, 25.36±11.02 vs. 13.17±10.14;
p=0.006). The significance was maintained when PI3K
mutant pts were stratified as low (<14%), intermediate
(14-20%) and high (>20%) Ki67 levels (p=0.009).
Despite the strong correlation, Ki67 did not appear significantly associated with median PFS to CDK4/6i, and the
presence of PI3K mutations remained an independent predictor of clinical outcome to CDK4/6i.
Conclusions: In conclusion, PI3K status should be considered a potential predictive biomarker of CDK4/6i and,
based on these data, the sequence of treatments (CDK4/6
vs. PI3Ki) may be reconsidered.
Clinical trial identification Circus study - ID 5694

E39
Platinum-based neoadjuvant
chemotherapy in triple-negative
breast cancer (TNBC) patients
with or without germline BRCA
mutation: a retrospective single
institution analysis
Diodati L.1, De Angelis C.1, Fontana A.1, Cavallero D.1, Lorenzini
G.1, Bargagna I.1, Cinacchi P.1, Fratini B.1, Salvadori B.1, Ferrari P.1,
Landucci E.1, Cucchiara F.1, Ghilli M.1, Roncella M.1, Del Re M.1,
Michelotti A.1, Falcone A.1
1

Azienda Ospedaliero-Universitaria Pisana, Pisa

Background: Neoadjuvant chemotherapy (CT) is currently considered the preferred approach for the majority
of early-stage TNBC patients (pts) according to the high
sensitivity to cytotoxic CT and the strong prognostic value
of achieving a pathological complete response (pCR).
However, only 30%-40% of TNBC pts achieve a pCR
after standard anthracycline-taxane based neoadjuvant CT.
The role of platinum agents and BRCA status remain
highly controversial in this setting of pts.
Material and methods: We retrospectively collected all
consecutive TNBC pts treated at our institution with neoadjuvant CT. We reported pts characteristics, outcomes
and adverse events (AEs).
Results: 116 pts were identified between 2002 and 2019.
Median age was 47 years (range 24-77); 58 pts (50%) were
premenopausal. Clinical stage at diagnosis was: I in 5 pts
(4%), II in 78 pts (67%) and III in 33 pts (29%). NST was
the most frequent histology (105 pts, 90%), followed by
lobular in 4 pts (3%) and other rare histotypes in 7 pts
(7%). 94 pts (81%) received a standard anthracycline±taxane
CT (P-), and 22 pts (19%) received platinum agents in
addition (P+). Outcome data were available for 113 pts
out of 116. P+ pts had a significant higher probability to
reach pCR compared to P- pts (47% vs 23%; OR 2.95,
95%CI 1.06-8.16; p=0,038). 68% of P+ pts received a
conservative surgery. 18 pts out of 116 (15%) reported

Tumori Journal 106(2S)
BRCA mutations, 14 pts (78%) in BRCA1 and 4 pts (22%)
in BRCA2. Among them, 4 pts (22%) were P+ and 14 pts
(78%) were P-; pCR rate was similar in both groups (25%
in P+ vs 21% in P-). G3/4 haematological AEs were more
frequent in P+ pts (68%) compared to P- pts (22%).
Neurotoxicity was similar in both groups. Early discontinuation of CT was more frequent in P+ vs P- pts (36% vs
5%). 31 pts out of 113(27%) experienced progression disease (PD), but only 4 of them had pCR after neoadjuvant
CT. Interestingly PD rate was lower in P+ pts compared to
P- pts (5% vs 31%).
Conclusions: In line with literature data, our real-life
experience showed that platinum-based neoadjuvant CT
was associated with significant increased pCR rates in
TNBC pts, at the cost of worse haematological toxicities.
BRCA germline mutation did not represent a sensitivity
factor to platinum agents. The addition of a platinum agent
to standard anthracycline-taxane-based CT may be considered an option in TNBC pts. Long-term outcome data are
required to further clarify the role of platinum as neoadjuvant treatment of TNBC pts.

E40
Could first-line triplet
Pertuzumab-Trastuzumab-Taxane
negatively affect progressionfree survival (PFS) of patients
treated with second-line
Trastuzumab-emtansine (TDM-1) in
metastatic HER2+ breast cancer? A
single monocentric experience
Sanò M.V.1, Castellana L.2, Dimarco R.1, Giuseppa F.1, Caffarelli
S.1, Alì M.1, Di Leo V.M.G.1, Chiarenza M.1, Aiello R.A.1, Picone A.1,
Caponnetto D.1, Caruso M.1
1

Humanitas Istituto Clinico Catanese, Catania; 2Università Palermo, Palermo

Background: The antibody-drug conjugate T-emtansine
(T-DM1) showed benefit in terms of both progression free
survival (PFS) and overall survival (OS) vs lapatinibcapecitabine in HER2+ patients treated at least with a previous T/taxane-based therapy ( EMILIA TRIAL). However
a paucity of data is available on T-DM1 efficacy after dual
blockade with pertuzumab plus trastuzumab, which rapresents the current first line standard of care. We conducted
a monocentric retrospective analysis on the sequence of
anti-Her2 treatments.
Matherial and Methods: Between June 15, 2014 and
January 31, 2020 we identified HER2+ (IHC: 3+ or 2+/
FISH amplified) mBC pts treated with T-DM1, either as
second-line after progression on dual blockade PT
(CohortPT) or after ⩽ 3 T-combined (chemo- or endocrinetherapies or both) regimens (Cohort T). We evaluated for
each Cohort demographics features, mPFS, best response



Tumori Journal Abstract Book - October 2020

Table of Contents for the Digital Edition of Tumori Journal Abstract Book - October 2020

Contents
Tumori Journal Abstract Book - October 2020 - Cover1
Tumori Journal Abstract Book - October 2020 - Cover2
Tumori Journal Abstract Book - October 2020 - I
Tumori Journal Abstract Book - October 2020 - II
Tumori Journal Abstract Book - October 2020 - Contents
Tumori Journal Abstract Book - October 2020 - IV
Tumori Journal Abstract Book - October 2020 - V
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