Tumori Journal Abstract Book - October 2020 - 118

118	
suppression (OFS) added to T or to an aromatase inhibitor
(AI) has radically changed the endocrine treatment landscape in this setting. In the joint analysis of TEXT and
SOFT, OFS plus exemestane (E) was superior in terms of
DFS to OFS plus T without difference in OS. In premenopausal women receiving an AI complete OFS must be
obtained usually using a gonadotropin-releasing hormone
agonist GnRHa. However, incomplete OFS is expected in
approximately 20% of the patients receiving a GnRHa plus
AI. Hence when a GnRHa plus an AI is chosen, a continuous monitoring of treatment adherence and the possible
signs that suggest potential recovery of ovarian functionare critical. Estradiol and FSH monitoring during treatment can be considered.
Patients and methods: From 6/2017 to 12/2019 twenty-one
consecutive premenopausal women with hormone positive
HER2 negative early breast cancer participated in the observational study. The treatment was leuprolide (L) 3.75 mg every 4
weeks plus E 25 mg daily. 14 pts received treatment after
chemotherapy (CT) and 7 as monotherapy (M). The serum
levels of E2, FSH and LH were assayed prior the administration of L plus E and then 1, 3, 6, 9 and 12 months after starting
therapy. The laboratory standard values for menopausal levels
are 10-40 pg/mL for E2 (limit detection 5 pg/ml), 25.8-134.8
mIU/ml for FSH and 7.7-58.5 mIU/ml for LH.
Results: All pts completed the observational period. The
baseline E2 value was menopausal in 8/14 CT pts and normal in all M pts. After 1 month E2 value was menopausal
in 12/14 CT pts and normal in all M pts. Three-months E2
values showed menopausal status in 13/14 CT pts and in
5/7 M pts. At six months from the start, the hormonal status remained unchanged therefore after discussion with
these pts switched toT. At 12 months all pts in L plus E
were in menopausal status. FSH and LH levels showed a
marked reduction from the start of treatment.
Conclusions: The majority of the pts (18/21), regardless
CT or M, had menopausal E2 value within six months
from the start, special attention should be given to chemotherapy-naïve pts.

Tumori Journal 106(2S)
baseline cytokines expression with cancer relapse and
outcome.
Material and methods: Baseline plasmatic samples of 66
stage I-III breast cancers treated with surgery with or without radiotherapy and systemic treatment between 2011 and
2017 were collected. A panel of 24 cytokines were analyzed by Luminex MAGPIX technology, using multiplex
Luminex Magnetic Assay kits (®R&D System).
Results: Sixty-six breast cancer patients were included in the
study. The median follow-up was of 78 months (range
18-99). The median age at diagnosis was of 58.5 years (range
32-86). The stage at diagnosis was I in 29 (43.9%) patients,
II in 26 (39.4%) and III in 11 (16.7%). The histological type
was ductal in 47 cases (71.2%), lobular in 13 (19.7%) and
mixed in 6 (9.1%). Fifty-three (80.3%) patients were estrogen-receptor-positive, 11 (16.7%) HER2-positive and 12
(18.2%) TNBC. All the patients received surgery, combined
with neo/adjuvant chemotherapy in 35 (53%) cases, antiHER2 in 9 (13.6%), hormonotherapy in 53 (80.3%) and
radiotherapy in 52 (78.8%). During the follow-up we
observed 11 relapses and 4 deaths. IL-4 was associated with
relapse, that occurs in 30.7% of the cases in the group with
IL-4 > 0.07 (IL4-H) mean fluorescence intensity (MFI) vs in
7.5% in the group with IL-4 ⩽ 0.07 MFI (IL4-L) (p 0.013),
with a ROC curve AUC of 0.745. In multivariate analysis
relapse was associated with IL-13 (p 0.048) and T stage (p
0.049). Survival analysis showed a better time to treatment
failure (TTF) for the group IL4-L (5y-TTF 87% vs 63% for
IL4-L and IL4-H, p 0.022) and for the group with IL-13 ⩽
0.1 MFI (IL13-L) compared IL-13 > 0.1 MFI (IL13-H) (5yTTF 90% vs 45%, p 0.017). A separation of the curves was
also observed for breast cancer specific survival (5y-BCSS:
95% vs 84% for IL4-L vs IL4-H, p 0.118; 91% vs 75% for
IL13-L vs IL13-H, p 0.029).
Conclusions: Higher baseline plasmatic level of IL-4 and
IL-13 are associated with a worse prognosis in early stage
breast cancer. These are two structurally and functionally
related cytokines known for regulating the immune system
activity, leading to a T helper-2 response and to a macrophage M2 polarization. Data should be confirmed in a
larger cohort and a mechanistic study is advisable.

E36
High plasmatic levels of IL-4 and IL13 are associated with recurrence
and worse survival in breast
cancer

E37

Onesti C.E.1, Onesti C.E.2, Josse C.3, Boulet D.3, Bours V.3, Jerusalem G.2

Testa I.1, Gallese M.1, Giuntini N.1, Nastasi G.1, Cattaneo E.1, Ionio
C.2, Andreol A.2, Smorti M.3, Peccatori F.A.4, Pravettoni G.4, Pisoni C.5,
Cassani C.5, Fenaroli V.1, Bonassi L.1

1

University Hospital of Liège Sart Tilman, Liège, Belgium; 2Department of
Medical Oncology, University Hospital of Liège Sart Tilman, Liège, Belgium;
3
Laboratory of Human Genetics, GIGA Research Institute, Liège, Belgium

Support breastfeeding following
breast cancer

1

ASST Bergamo Est, Seriate; 2Università Cattolica del Sacro Cuore, Milano;
Università degli Studi di Pisa, Pisa; 4Istituto Europeo d'Oncologia, Milano;
5
IRCCS San Matteo di Pavia, Pavia
3

Background: The immune system has a role in breast
tumor, in particular in triple negative (TNBC) and in hormone receptor-negative/HER2-positive breast cancers.
The aim of this study is to analyze the association between

Background: Breast Cancer (BC) is the most common
oncological disease diagnosed in pre-menopausal women.



Tumori Journal Abstract Book - October 2020

Table of Contents for the Digital Edition of Tumori Journal Abstract Book - October 2020

Contents
Tumori Journal Abstract Book - October 2020 - Cover1
Tumori Journal Abstract Book - October 2020 - Cover2
Tumori Journal Abstract Book - October 2020 - I
Tumori Journal Abstract Book - October 2020 - II
Tumori Journal Abstract Book - October 2020 - Contents
Tumori Journal Abstract Book - October 2020 - IV
Tumori Journal Abstract Book - October 2020 - V
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