Tumori Journal Abstract Book - October 2020 - 115

E - Breast Cancer	
We evaluated the CB in terms of Partial Response (PR),
Complete Response Rate (CR) and Stability of Disease
(SD); compared then G3/4 neutropenia rates with CB and
Progression Disease (PD) pts and their relationship with
progression free survial (PFS) at 1 year follow-up (FU).
Results: We enrolled 50 female pts: 26 had not performed
previous treatments (52%). Palbociclib was associated
with aromatase inhibitor and fulvestrant respectively in
54% and 46% of pts.
The only G3-G4 toxicity reported was neutropenia which
occurred in 24 pts (48%), with 1 case of febrile neutropenia (2%). At least one therapeutic cycle was delayed in 31
pts (62%) but only 8 (16%) had to reduce the dosage of the
CDK-inhibitor.
PD rate at first diagnostic evaluation was 14% (7). PR was
12% (6), CR 2% (1), SD 72% (36) translating into a CB in
86% (43) of the pts. No G3/4 neutropenia differences were
observed in these 3 subgroups.
G3/4 neutropenia was reported in 67% (29) of CB pts and
57% (4) of PD pts.
At 12 months of FU, 33 pts were evaluable: 36% (12) had
PD while 63,4% (21) had still CB. No difference in G3/4
neutropenia was observed between PD and CB pts at 1
year FU (33% vs 38%).
Conclusions: No significant difference in G3/4 neutropenia incidence was observed in CB pts compared with PD
pts; also at 1 year FU no difference in PFS was registered.
Yet these results can be reassuring because high rate hematologic toxicities and frequent postponed cycles do not
compromise pts clinical outcome.

E30
Primary treatment strategy in
elderly patients with hormone
receptor positive early breast
cancer: is breast cancer surgery
always better?
Nasso C.1, Barbolini M.1, Isca C.1, D'onofrio R.1, Cortesi G.1, Dominici
M.1, Piacentini F.1, Omarini C.1
1

AOU Policlinico Modena, Modena

Background: Older age, ECOG performance status,
major comorbidities and concomitant medications influence the primary treatment strategy of hormone receptor
positive (HR+) early breast cancer (EBC) patients. In case
of frail patients, oncologist may choose primary endocrine
therapy (ET) instead of breast cancer surgery (BCS) even
if its clinical impact is still unknown.
Methods: We performed a retrospective study on women
aged 75 years and older with HR+ EBC diagnosed at the
Modena Cancer Center from 2010 to 2016. According to
primary treatment strategy patients were divided into two
groups: patients who underwent BCS (BCS group) versus

115
patients treated with only ET (ET group). Patients' clinical
data and tumor characteristics were collected. Disease Free
Survival (DFS) and Breast cancer-specific survival (BCSS)
were estimated by long rank test and Kaplan-Meier curves.
Results: 143 patients were involved in the study: 105 in
BCS group and 38 in ET one. Patients who underwent surgery had significantly better ECOG (p=0.000001), low
tumour grade (p=0.04) and early clinical stage (p=0.0001)
compared to those in the ET group. In patients with negative lymph-nodes at the diagnosis, tumor stage I-II and low
ki67 (<20%), BCS did not improve 5-years DFS in univariate and multivariate analysis (p = 0.099, 95%CI
0.152-1.175). No differences were found in terms of
5-years BCSS between the two groups (p = 0.195).
Conclusions: Stage I-II at the diagnosis, negative axillary
lymph nodes and low ki67 identified a subgroup of HR+
EBC patients aged > 75 with low risk of disease progression who may not benefit from primary BCS. In elderly
frail patients, primary ET instead of BCS could be a valid
treatment strategy that should be considered on a case-bycase basis.

E31
Hematological toxicity in
patients (pts) treated with
Palbociclib and Fulvestrant (P+F):
older age and prior adjuvant
therapies as predictive factors of
Palbociclib-induced neutropenia
Bitca V.1, Raimondi L.1, Gozzi E.1, Mannino A.1, Pietranera M.2,
Spinelli G.P.3, Rossi L.3
1

Università La Sapienza Roma, Aprilia; 2Centro Medico Diagnostico-Salus,
Civitavecchia; 3Oncologia Territoriale, Aprilia

Background: Despite P+F is an treatment for hormone
receptor-positive (HR+), HER2-negative metastatic breast
cancer (MBC), neutropenia continues to remain the major
dose limiting toxicity. In this study, we evaluated the role of
age and previous therapy for predicting Grade 3 (G3) or
Grade4 (G4) or febrile (FN) neutropenia in HR+/HER2MBC treated with P+F as first-line metastatic therapy.
Methods: We retrospectively analyzed a consecutive cohort
of 106 pts diagnosed with HR+/HER2-MBC treated with
P+F as first line metastatic therapy between December
2017 and March 2020. Demographics, prior treatments,
blood tests and hematological toxicities were recorded.
Results: The pts'median age was 61 (range 33-81).
Neutropenia was reported in 78 (73%) pts: slightly less
than half (44,3%) of pts experienced G3, 31 pts (29,2%)
G4 and 14pts (13,2%) febrile neutropenia. Dose delays
were in median a week. Beacause of hematological toxicity reported, 61 pts (57%) had a dose reduction, down to
100 mg in 51 pts (48,1%) and 75 mg in 10 pts (9,4%).



Tumori Journal Abstract Book - October 2020

Table of Contents for the Digital Edition of Tumori Journal Abstract Book - October 2020

Contents
Tumori Journal Abstract Book - October 2020 - Cover1
Tumori Journal Abstract Book - October 2020 - Cover2
Tumori Journal Abstract Book - October 2020 - I
Tumori Journal Abstract Book - October 2020 - II
Tumori Journal Abstract Book - October 2020 - Contents
Tumori Journal Abstract Book - October 2020 - IV
Tumori Journal Abstract Book - October 2020 - V
Tumori Journal Abstract Book - October 2020 - 1
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Tumori Journal Abstract Book - October 2020 - Cover3
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