Tumori Journal Abstract Book - October 2020 - 113

E - Breast Cancer	
Department of Oncology of Udine, were retrospectively
analyzed. Pts with de novo advanced BC were not included.
We described baseline features at the diagnosis of early BC
(eBC) and modalities of detection of rBC.
Results: At diagnosis of eBC the most common immunophenotype was Luminal HER2-neg subgroup (63%), followed by triple negative (TN) subgroup (17%) and
HER2-pos subgroup (15%) and the main disease characteristics were pT1 (46%), N+ (57%), Ki-67⩾14% (60%). The
median time to recurrence was 66.6 months. At the diagnosis of rBC, 54% of pts presented with visceral metastases
and 2% with visceral crisis. 53% of pts had ECOG PS 0. Of
note, 25% of pts had a previous loco-regional recurrence
treated with radical resection. Overall, almost half of the pts
was symptomatic (46%); among this pts, 40% reported
pain, 21% thoracic symptoms, 19% had locoregional symptoms/signs of relapse, 12% neurological symptoms and 8%
constitutional symptoms. 47%, 34% and 7% of rBCs in
asymptomatic pts were detected by radiological exams,
serum markers and other changes in blood test, respectively.
Of note, the majority of rBC were detected by oncologist
(43%), followed by other specialists (33%) and general
practitioner (14%). 30% of rBC diagnosis were made during
a scheduled oncological follow-up visit. Biochemical alterations were mainly evident in ER-pos (OR 4.61, 95%CI
1.01-21.22, p=0.05), while clinical symptoms were detected
mainly in Ki-67⩾14% pts (OR 2.75, 95%CI 1.01-7.51,
p=0.04). The multivariate logistic regression model did not
confirm these results. None of analyzed factors were associated with detection through radiological exams.
Conclusions: We report the modality of detection of rBC
in a monocentric real word experience. Albeit purely
descriptive, our results could be relevant in drawing prospective randomized studies to explore the prognostic
impact of surveillance programmes.

E26
Lactate dehydrogenase as a
prognostic biomarker in patients
with hormone receptor-positive
metastatic breast cancer treated
with palbociclib
Pelizzari G.1, Bertoli E.1, Basile D.1, Giavarra M.1, Gerratana L.2,
Michelotti A.1, Avoledo D.3, Da Ros L.3, Bonotto M.4, Bolzonello S.3,
Di Nardo P.3, Fasola G.4, Mansutti M.4, Spazzapan S.3, Minisini
A.M.4, Puglisi F.2

113
(HR)-positive/HER2-negative metastatic breast cancer
(MBC). Serum lactate dehydrogenase (LDH) has been correlated with poor prognosis in various malignancies,
including MBC. However, no data are available for patients
treated with CDK4/6 inhibitors. Henceforth, this study
aimed to explore the prognostic impact of elevated plasmatic LDH levels in patients with luminal MBC treated
with endocrine therapy (ET) and palbociclib.
Material and Methods: This retrospective study analyzed
data of patients with HR-positive/HER2-negative MBC
treated consecutively with palbociclib at two Italian cancer
centers from 2017 to 2019. A multivariate Cox regression
model evaluated the independent prognostic impact of
baseline plasmatic LDH levels for both progression-free
survival (PFS) and overall survival (OS). Relevant clinicopathological factors included in the model were: age, progesterone receptor (PgR) status, tumor grade, performance
status, treatment line, bone-only or visceral disease, tumor
burden, companion ET.
Results: Overall, 202 patients were deemed eligible. Of
these patients, 133 (65.8%) received palbociclib plus fulvestrant, 69 (34.2%) palbociclib plus aromatase inhibitors, and
111 (55.0%) were treated first-line. 37.2% of cases were
PgR-negative, and 33.2% were grade 3 tumors. Visceral
involvement was detected in 46.5% of patients, whereas
34.1% presented with bone-only disease. Of note, 60.9% of
patients received a prior chemotherapy, 25.2% in the metastatic setting. After a median follow-up of 15.2 months, the
median PFS was 14.1 months (95%CI: 10.97-18.17), and the
median OS was not reached. At baseline, 20% of evaluable
patients (24/120) had elevated pre-treatment LDH levels
according to the local laboratory cut off. Through multivariate analyses, baseline LDH levels emerged as negative independent prognostic factor in terms of both PFS (HR: 2.18,
95%CI: 1.12-4.25, p=0.02) and OS (HR: 4.65, 95%CI: 1.5913.55, p=0.004). Consistently, high LDH levels correlated
with shorter median PFS (9.5 vs. 17.4 months, p=0.01) and
median OS (15.3 months vs. not reached, p=0.0004).
Conclusions: Serum LDH levels independently predict
PFS and OS in patients with luminal MBC treated with
palbociclib. Despite the small sample size and the limited
follow-up, this is the first study to confirm the prognostic
role of LDH during treatment with CDK4/6 inhibitors.

E27 - The Abstract has been withdrawn at the
request of the Authors

1

Dipartimento di Area Medica (DAME), Università degli Studi di Udine, Udine,
italy, Udine; 2Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano
(PN), Italy; Dipartimento di Area Medica (DAME), Università degli Studi di
Udine, Udine, italy, Udine; 3Centro di Riferimento Oncologico di Aviano (CRO),
IRCCS, Aviano (PN), Italy, Aviano (PN); 4Dipartimento di Oncologia di Udine,
Azienda Sanitaria Universitaria Friuli Centrale (ASUFC), Udine, Italy, Udine

Background: Cyclin-dependent kinases (CDK) 4/6 inhibitors reshaped the therapeutic scenario for hormone receptor

E28
Prognostic factors associated
with clinical outcomes in HR+,
HER2- advanced breast cancer
(ABC): Systematic literature
review



Tumori Journal Abstract Book - October 2020

Table of Contents for the Digital Edition of Tumori Journal Abstract Book - October 2020

Contents
Tumori Journal Abstract Book - October 2020 - Cover1
Tumori Journal Abstract Book - October 2020 - Cover2
Tumori Journal Abstract Book - October 2020 - I
Tumori Journal Abstract Book - October 2020 - II
Tumori Journal Abstract Book - October 2020 - Contents
Tumori Journal Abstract Book - October 2020 - IV
Tumori Journal Abstract Book - October 2020 - V
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