Tumori Journal Abstract Book - October 2020 - 112

112	
CD73⩽40%. A multivariate analysis was performed to
consider the effects of variables on the pCR. Akaike information criterion (AIC) and Bayesian information criterion
(BIC) were used for model selection. The optimal model is
selected based on the minimum AIC and BIC.
Results: We retrospectively analysed 60 biopsies from
patients with TNBC who received standard NACT.
Pathological complete response was achieved in 23 patients
(38%). Seventeen cases (28.3%) had H-TILs and 31 (51.6%)
had low-CD73, significantly associated with pCR (p=0.001,
p=0.009, respectively). PD-L1= 1% was found in 49 patients
(81.7%). No significant difference in pCR has been highlighted between PD-L1 positive and negative patients
(p=0.734). Twelve (19.7%) cases could be considered
TIP+. The pCR rate was significantly different between
TIP+ (91.7%; 11/12 patients) and TIP- (25%; 12/48)
patients (p <0.0001). Using a multivariate analysis TIP was
confirmed as an independent predictive factor of pCR [OR
49.7 (6.30-392.4)], p<0.0001). Finally, the combined
immune-profile is more accurate in predicting pCR (AIC
68.3; BIC 74.5) as compared to single biomarkers.
Conclusions: An association between immune background and response to neoadjuvant chemotherapy has
been found and TIP, based on the contemporary expression
of PD-L1, TILs and CD73, has been identified as a possible independent predictive biomarker of pCR, highlighting
the need to consider an immunological patients' profile
rather than single biomarkers.

E24
Impact of BMI on outcome and
cardiac safety in HER2 positive
Breast Cancer patients treated
with adjuvant Trastuzumab.
Results of a monocentric
observational study
Molinelli C.1, Del Mastro L.2, Giraudi S.3, Ballestrero A.4, Carli F.4,
Poggio F.4, D'Alonzo A.4, Dellepiane C.4, Buzzatti G.4, Blondeaux E.4,
Conte B.4, Pastorino S.4, Pirrone C.4, Favero D.4, Gallo M.4, Ruelle T.4,
Lambertini M.4, Bighin C.4
1

Ospedale Policlinico San Martino, genova; 2IRCSS Ospedale Policlinico San
Martino, Genova; 3Ospedale San Paolo, Savona; 4IRCCS Ospedale Policlinico
San Martino, Genova

Background: The impact of Body Mass Index (BMI) on
receptor positive (HR+) breast cancer (BC) risk of recurrence has been deeply investigated but there are still few
data concerning the BMI role in HER2 positive (HER2+)
BC patients (pts). The aim of our study is to evaluate the
impact of BMI on HER2 positive BC pts treated with adjuvant Trastuzumab in terms of disease-free survival and
cardiac toxicity.
Materials and Methods: From 1992 to 2016, 694 consecutive HER2+ BC pts were enrolled in a monocentric

Tumori Journal 106(2S)
observational study. Among these pts we selected 201 pts
treated with adjuvant Trastuzumab after surgery of the primary tumor and with available BMI data. Exclusion criteria were neoadjuvant chemotherapy (117 pts), metastatic
disease ab initio (26 pts), treatment with adjuvant
Pertuzumab or Lapatinib (30 pts), not receiving adjuvant
Trastuzumab (92 pts), missing adjuvant therapy data (27
pts) and missing BMI data (201 pts). 5-year disease free
survival (5yDFS) rates analyses were performed using
Kaplan Meyer method to evaluate differences between the
following groups: BMI<25 vs BMI⩾25, HR+ BMI<25
vs HR+ BMI⩾25, receptor negative (HR-) BMI<25 vs
HR- BMI⩾25. Moreover, in 151 pts with available cardiac
data, we analyzed the number of cardiac events, defined as
a left ventricular ejection fraction (LVEF) decline of
⩾10% from baseline and/or LVEF<50%, in BMI<25 pts
and in BMI⩾25 pts, using χ(2) test.
Results: Median age was 56 years (28-85), 72 pts (36%)
were premenopausal and 129 pts (64%) were post-menopausal. 123 pts (61%) had BMI<25 and 78 (39%) had BMI⩾25.
HR were negative in 79 pts (39%) and positive in 122 pts
(61%). At a median follow up of 7.2 yrs, there was no difference in 5yDFSbetween BMI<25 pts and BMI⩾25 pts (93%
vs 94%, p=0.653). 5yDFSwas 95% in HR+ BMI<25 vs
97% HR+ BMI⩾25 (p=0.535), 91% in HR- BMI<25 vs
91% HR- BMI⩾25 (p=0.730), consistent with overall population result. In 151 pts with available cardiac toxicity data
we identified 15 cardiac events (15%) in BMI<25 group and
10 cardiac events in BMI⩾25 group (19%) (p=0.522).
Conclusions: Our retrospective analysis did not show a
significant impact of BMI on 5yDFS or cardiotoxicity in
early HER2+ BC pts treated with adjuvant Trastuzumab.

E25
An Italian real word experience
about modality of detection of
recurrent breast cancer
Palmero L.1, Zara D.1, Targato G.1, Giavarra M.1, Basile D.2, Vitale
M.G.1, Bertoli E.2, Bortot L.1, Noto C.1, Poletto E.3, Pascoletti G.3,
Andreetta C.3, Russo S.3, Mansutti M.3, Bonotto M.3, Fasola G.3,
Puglisi F.2, Minisini A.M.3
1

Dipartimento di Area Medica (DAME) - University of Udine; Dipartimento di
Oncologia, Azienda Sanitaria Universitaria Friuli Centrale, Udine, Italy, Udine;
2
Dipartimento di Area Medica (DAME) - University of Udine; Dipartimento
di Oncologia Medica, IRCCS, Centro di Riferimento Oncologico di Aviano
(CRO), Aviano, Italy, Udine; 3Dipartimento di Oncologia, Azienda Sanitaria
Universitaria Friuli Centrale, Udine, Italy, Udine

Background: There is a lively debate in the oncologic community about the role of follow-up and its impact on the
clinical outcome in recurrent breast cancer (rBC). In this
study we report the modalities of detection of inoperable
rBC. Material (patients) and methods: 169 pts with rBC
diagnosis from January 2012 to December 2016 at the



Tumori Journal Abstract Book - October 2020

Table of Contents for the Digital Edition of Tumori Journal Abstract Book - October 2020

Contents
Tumori Journal Abstract Book - October 2020 - Cover1
Tumori Journal Abstract Book - October 2020 - Cover2
Tumori Journal Abstract Book - October 2020 - I
Tumori Journal Abstract Book - October 2020 - II
Tumori Journal Abstract Book - October 2020 - Contents
Tumori Journal Abstract Book - October 2020 - IV
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