Tumori Journal Abstract Book - October 2020 - 107

E - Breast Cancer	
the real-life setting. Further studies are needed to investigate the biologic mechanisms underlying these findings.

E15
Clinical and biochemical features
of rapidly progressive disease
during first-line therapy in
hormone receptor (HR) positive
HER2 negative metastatic breast
cancer
Corvaja C.1, Basile D.2, Bertoli E.2, Franceschin G.3, Pelizzari G.3,
Gerratana L.2, Zara D.1, Palmero L.1, Alberti M.2, Bonotto M.4, Da
Ros L.5, Cinausero M.6, Minisini A.M.6, Spazzapan S.5, Mansutti M.6,
Fasola G.6, Puglisi F.2
1
Dipartimento di Area Medica (DAME), Università degli studi di Udine;
Dipartimento di Oncologia, Azienda Sanitaria Universitaria Friuli Centrale
(ASUFC), Udine, Italy, Udine; 2Dipartimento di Area Medica (DAME),
Università degli studi di Udine; IRCCS, Centro di Riferimento Oncologico
(CRO), Aviano, Italy, Udine; 3Dipartimento di Area Medica (DAME),
Università degli studi di Udine, Udine; 4 Dipartimento di Oncologia, Azienda
Sanitaria Universitaria Friuli Centrale (ASUFC), Udine, Italy, Udine; 5IRCCS,
Centro di Riferimento Oncologico (CRO), Aviano, Italy, Udine; 6Dipartimento
di Oncologia, Azienda Sanitaria Universitaria Friuli Centrale (ASUFC), Udine,
Italy, Udine

Background: Recent breakthroughs in anti-cancer therapy have consistently improved prognosis in luminal metastatic breast cancer (LMBC) patients (pts). However, a
subset of pts develops more aggressive and rapidly progressive diseases. Aim of this study was to evaluate the
impact of clinico-patological features on fast progression
during first-line therapy.
Material and methods: We retrospectively analyzed a
consecutive cohort of 717 LMBC pts treated from 2008 to
2019 at the Oncology Departments of Udine and Aviano
Cancer Centre, Italy. The association between baseline
clinico-pathological features and rapidly progressive disease, defined as progression within the first six months of
treatment, was assessed by uni- and multivariate logistic
regression.
Results: Overall, 41% pts were aged>65 and 78% were
post-menopausal. ECOG PS was >1 in 15% pts, and
Ki-67=14% was detected in 60%. Almost 29% had de
novo LMBC. Visceral involvement was detected in 49%
whereas 30% had bone-only disease. Interestingly, 23%
pts had ⩾3 metastatic sites and >5 metastatic lesions.
Only 38% pts were ET naïve whereas 56% were CT naïve.
First-line therapy included ET alone or combined with
CDK4/6 in 49% and 20% pts, respectively, and CT in 31%
pts. By univariate analysis on the overall cohort, age (4565: OR 2.49, 95%CI 1.29-4.83 p=0.007; >65: OR 2.40,
95%CI 1.23-4.66 p=0.010), ECOG PS>1 (OR 2.36,
95%CI 1.50-3.72, p<0.001), visceral crisis (OR 8.68,
95%CI 1.73-43.53 p=0.009), MLR>0.28 (OR 2.08,

107
95%CI 1.24-3.49 p=0.006), LDH >480UI (OR 1.88,
95%CI 0.99-3.58, p=0.054), menopause status (OR 2.10,
95%CI 1.21-2.97 p=0.009), prior ET (OR 2.21, 95%CI
1.46-3.33 p<0.001) and visceral involvement (OR 1.89,
95%CI 1.21-2.97 p=0.005) were associated with fast progression. By multivariate analysis, ECOG PS>1 (OR
4.94, 95%CI 1.56-15.69 p=0.007), prior ET (OR 3.39,
95%CI 1.32-8.68 p=0.011) and high baseline LDH levels
(OR 2.93, 95%CI 1.28-6.74 p=0.011) were independently
associated with fast progression. No differences were
observed according to treatment type (ET vs ET-CDKi:
OR 0.95, 95%CI 0.54-1.68 p=0.879; CT vs ET-CDKi: OR
0.95, 95%CI 0.52-1.72 p=0.869)
Conclusions: In our analysis, ECOG PS>1, prior ET and
high LDH levels represent the baseline features determining rapidly progressive diseases in LMBC. Although the
retrospective nature, our results might support further trials specifically designed to evaluate tailored disease monitoring, targeted treatments and new biomarkers as ctDNA.

E16
Mutation agnostic ctDNA-based
workflow for early response
evaluation in HR positive, HER2
negative Metastatic Breast
Cancer: a proof of concept
prospective study
Bortot L.1, Corvaja C.2, Franzoni A.3, Allegri L.4, Basile D.5, Viotto D.6,
Bertoli E.5, Buriolla S.5, Targato G.2, Da Ros L.7, Russo S.8, Di Nardo
P.7, Alberti M.5, Mazzeo R.5, Bonotto M.8, Belletti B.9, Gerratana
L.10, Baldassarre G.9, Damante G.3, Puglisi F.5
1
Dipartimento di Area Medica (DAME) Università degli studi di Udine;
Dipartimento di Oncologia Azienda Sanitaria Universitaria Friuli Centrale,
Udine, Italy, Udine; 2Dipartimento di Area Medica (DAME), Università degli
studi di Udine; Dipartimento di Oncologia Azienda Sanitaria Universitaria
Friuli Centrale, Udine (Italia), Udine; 3Istituto di Genetica Medica, Azienda
Sanitaria Universitaria Friuli Centrale, Udine (Italia), Udine; 4Dipartimento di
Area Medica (DAME), Università degli studi di Udine;, Udine; 5Dipartimento
di Area Medica (DAME), Università degli studi di Udine; IRCCS CRO Centro
di Riferimento Oncologico Aviano, Udine; 6Unità di Oncologia Molecolare,
IRCCS CRO Centro di Riferimento Oncologico Aviano, Aviano; 7IRCCS CRO
Centro di Riferimento Oncologico Aviano, Aviano; 8Dipartimento di Oncologia
Azienda Sanitaria Universitaria Friuli Centrale, Udine (Italia), Udine; 9Unità di
Oncologia Molecolare, IRCCS CRO Centro di Riferimento Oncologico Aviano,
Udine; 10IRCCS CRO Centro di Riferimento Oncologico Aviano; Udine

Background: Endocrine therapy (ET) is the treatment of
choice for HR positive, HER2 negative Metastatic Breast
Cancer (Luminal MBC) but there is a paucity of markers
apt to characterize early disease dynamics. The aim of the
study was to proof the concept of a mutation-agnostic
workflow based on circulating tumor DNA (ctDNA) for
early response monitoring.
Methods: A multicenter cohort of 49 women with Luminal
MBC was prospectively enrolled and characterized for



Tumori Journal Abstract Book - October 2020

Table of Contents for the Digital Edition of Tumori Journal Abstract Book - October 2020

Contents
Tumori Journal Abstract Book - October 2020 - Cover1
Tumori Journal Abstract Book - October 2020 - Cover2
Tumori Journal Abstract Book - October 2020 - I
Tumori Journal Abstract Book - October 2020 - II
Tumori Journal Abstract Book - October 2020 - Contents
Tumori Journal Abstract Book - October 2020 - IV
Tumori Journal Abstract Book - October 2020 - V
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