Tumori Journal Abstract Book - October 2020 - 100

100	
previously exposed to adjuvant T. No new concerns about
toxicity. Final results on OS will be presented.

E05*
Identification of prognostic
and predictive pharmacogenomic
biomarkers by DMET platform:
a retrospective multicentric
study in advanced breast cancer
patients treated with CDK4/6
inhibitors
Cucè M.1, Staropoli N.2, Arbitrio M.3, Labanca C.4, Scionti F.4,
Ciliberto D.4, Strangio A.4, Tafuni M.4, Romeo C.4, Barbieri V.4,
Renne M.5, Correale P.6, Tassone P.7, Tagliaferri P.8
1
Medical Oncology Unit Department of Experimental and Clinical Medicine,
Magna Græcia University and Cancer Center, Campus Salvatore Venuta,
Catanzaro; 2Medical Oncology Unit, Department of Experimental and
Clinical Medicine, Magna Græcia University and Cancer Center, Campus
Salvatore Venuta, Catanzaro; 3CNR-Institute for Biomedical Research and
Innovation, 88100 Catanzaro, Italy, Catanzaro; 4Medical Oncology Unit
Department of Experimental and Clinical Medicine, Magna Græcia University
and Cancer Center, Campus Salvatore Venuta, Catanzaro, Italy;, Catanzaro;
5
Surgery Unit Department of Experimental and Clinical Medicine, Magna
Græcia University and Cancer Center, Campus Salvatore Venuta, Catanzaro,
Italy, Catanzaro; 6Medical Oncology Unit, "Bianchi-Melacrino-Morelli"
Grand Metropolitan Hospital, Reggio di Calabria, Italy, Reggio Calabria;
7
Translational Medical Oncology Unit, Department of Experimental and
Clinical Medicine, Magna Græcia University and Cancer Center, Campus
Salvatore Venuta, Catanzaro, Italy, Catanzaro; 8Medical Oncology Unit,
Department of Experimental and Clinical Medicine, Magna Græcia University
and Cancer Center, Campus Salvatore Venuta, Catanzaro, Italy, Catanzaro

Background: The CDK 4/6 inhibitors (CDK4/6i) produced
a clear improvement in the hormone receptor positive (HR+)
and HER2-negative metastatic breast cancer (MBC) therapeutic scenario, with a significant benefit both in term of progression free survival (PFS) and overall survival (OS).
Despite the efficacy results, intrinsic or acquired resistance
to CDK4/6i represent a limiting factor for the success of
these treatments. Mechanisms underlying resistance are multifactorial and patient's genetic make-up may play a role in
interindividual variability. We performed a case-control retrospective study in MBC patients to identify potential predictive and prognostic pharmacogenomics biomarkers
related to the CDK4/6i response to treatment by the microarray-based DMET platform which allows genotyping of 1936
single nucleotide polymorphisms (SNPs) in ADME genes
(Absorption, Distribution, Metabolism, Excretion).
Patients and Methods: Patients with HR+, HER2negative MBC, treated with CDK4/6i and with age ⩾ 18
years old were eligible with written informed consent.
Between December 2017-November 2019, we enrolled 41
matched patients in two groups: responders to therapy
(case) and resistant to therapy (control) if disease progression occurred within 6 months. Moreover, we evaluated the
correlation among the main clinical-laboratory parameters

Tumori Journal 106(2S)
with (PFS) and response to treatment. Samples from
peripheral blood were collected and analyzed by DMET
platform. Genotyping profiles of each patient were calculated by the DMET Console® software and genotype frequencies between cases and controls were evaluated by
DMET-Analyzer tool by two-tailed Fisher exact test. Power
of Genetic Analysis system was used to investigate the
association of identified SNPs and PFS.
Results: Two SNPs in CYP2B6 (rs8192709, p=0.0475) and
UGT2B4 gene (rs1966151, p=0.0023) showed a statistically
significant association with response, despite the small sample size. Moreover, a SNP in ABCB1 (rs2235015, p=0.0261)
results associated to treatment-induced neutropenia.
Conclusions: Our results demonstrated association
between the SNPs here reported and response to treatment.
The pharmacokinetic pathways in which a drug is involved
are very complex and the presence of specific polymorphisms in ADME genes can produce changes in drug
activity and/or toxicity and can provide valuable biomarkers for clinical practice. Follow up validation studies must
be extended to a larger sample.

E06
Association between the
neutrophil-to-lymphocyte and
platelet-to-lymphocyte ratios
and efficacy of CDK 4/6 inhibitors
in Advanced Breast Cancer: the
observational multicenter
Italian PALMARES study
Zattarin E.1, Zattarin E.1, Fabbroni C.1, Ligorio F.1, Marra A.2, Corti
C.2, Bernocchi O.3, Sirico M.4, Generali D.4, Curigliano G.2, Bianchi
G.1, Capri G.1, Rivoltini L.5, De Braud F.1, Vernieri C.1
1

Istituto Nazionale dei Tumori, Milano; 2Istituto Europeo di Oncologia,
Milano; 3Department of Medical, Surgery and Health Sciences, Università di
Trieste, Trieste; 4Azienda Socio Sanitaria Territoriale di Cremona, Cremona;
5
Unit of Immunotherapy of Human Tumors, Fondazione IRCCS Istituto
Nazionale per lo Studio e la Cura dei Tumori, Milano

Background: According to preclinical evidence, CyclinDependent Kinase 4/6 inhibitors (CDK 4/6i) stimulate antitumor immunity as part of their antineoplastic activity. The
neutrophil-to-lymphocyte ratio (NLR) and the platelet-tolymphocyte ratio (PLR) reflect systemic inflammation and
immune system functional status. We aimed at investigating their association with CDK 4/6i efficacy in patients
(pts) with hormone receptor-positive advanced breast cancer (HR+ aBC).
Patients and Methods: A retrospective, observational,
multicenter Italian study was conducted to investigate the
association between NLR or PLR, as measured at baseline
and after the first 3 treatment cycles, and progression free
survival (PFS) in HR+ HER2- aBC pts treated with CDK
4/6i plus endocrine therapies (ETs). The thresholds for



Tumori Journal Abstract Book - October 2020

Table of Contents for the Digital Edition of Tumori Journal Abstract Book - October 2020

Contents
Tumori Journal Abstract Book - October 2020 - Cover1
Tumori Journal Abstract Book - October 2020 - Cover2
Tumori Journal Abstract Book - October 2020 - I
Tumori Journal Abstract Book - October 2020 - II
Tumori Journal Abstract Book - October 2020 - Contents
Tumori Journal Abstract Book - October 2020 - IV
Tumori Journal Abstract Book - October 2020 - V
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