Tumori Journal Abstract Book - October 2020 - 1

953388
abstract2020

TMJ0010.1177/0300891620953388

AIOM abstracts

Tj

Tumori
Journal

Tumori Journal
2020, Vol. 106(2S) 1--215
© Fondazione IRCCS Istituto
Nazionale dei Tumori 2020
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https://doi.org/10.1177/0300891620953388
DOI: 10.1177/0300891620953388
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Plenary Session
LBA01*
INfluenza Vaccine Indication
During therapy with Immune
checkpoint inhibitors: a
transversal challenge. The
multicenter, prospective,
observational INVIDIa-2 study (a
FICOG study)
Bersanelli M.1, Giannarelli D.2, Verzoni E.3, Procopio G.3,
Clemente A.4, Signorelli D.3, Costanzo R.5, De Vivo R.6, Zara D.7,
Zacheo A.8, Scotti V.9, Guglielmini P.F.10, Giusti R.11, Bimbatti D.12,
Rossi E.13, Rijavec E.14, Tiseo M.1, Pignata S.5, Di Maio M.15,
Buti S.1, De Giorgi U.4
1
Azienda Ospedaliero-Universitaria di Parma, Parma; 2Istituto Nazionale
Tumori Regina Elena, Roma; 3IRCCS Istituto Nazionale Tumori di Milano,
Milano; 4Istituto Scientifico Romagnolo per lo Studio e la Cura de Tumori
(IRST) IRCCS, Meldola; 5IRCCS Istituto Nazionale Tumori G. Pascale, Napoli;
6
Ospedale San Bortolo Azienda ULSS8 Berica - Distretto Est, Vicenza;
7
Azienda Sanitaria Universitaria Friuli Centrale, Udine; 8IRCCS Istituto Tumori
"Giovanni Paolo II", Bari; 9Azienda Ospedaliero Universitaria Careggi, Firenze;
10
Azienda Ospedaliera di Alessandria, Firenze; 11Azienda OspedalieroUniversitaria Sant'Andrea, Roma; 12Istituto Oncologico Veneto IOV - IRCCS,
Padova; 13Policlinico Gemelli - Università La Sapienza, Roma; 14Fondazione
IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano; 15Ospedale
Mauriziano - Università degli Studi di Torino, Torino

Background: The susceptibility of advanced cancer
patients treated with immune checkpoint inhibitors (ICI)
for viral infections has not been investigated. Currently,
there are no robust data supporting the efficacy, safety and
recommendation for influenza vaccination in cancer
patients receiving ICI. The retrospective INVIDIa study
suggested that flu vaccine could be ineffective in these
patients.
Methods: The prospective, multicenter, observational
INVIDIa-2 study investigated the clinical efficacy

of influenza vaccination in advanced cancer patients
receiving ICI between October 2019 and January 2020.
The primary endpoint was the incidence of influenza-like
illness (ILI) until April 30, 2020. Secondary endpoints
regarded ILI severity and lethality and flu vaccine safety.
Results: The study enrolled 1279 patients; 1177 patients
were evaluable for the primary endpoint analysis. Of
them, 48.8% (574) received flu vaccination. The ILI incidence was 7.7% (91 patients). Patients receiving the flu
vaccine were significantly more frequently elderly
(p<0.0001), former or active smokers (p<0.0001),
affected by lung cancer (p=0.017) and by non-cancer
comorbidities (p<0.0001) when compared to unvaccinated patients. The ILI incidence was not different
according to influenza vaccination: the incidence of ILI
was 8.2% in vaccinated vs 7.3% in unvaccinated patients
(p=0.57). The time-adjusted ILI incidence, in terms of
influenza-free survival (IFS), was similar in vaccinated
and unvaccinated patients (6-months IFS 91.4% vs 89.7%
respectively, p=0.92). Nevertheless, the vaccine administration was related to significantly lower rate of ILI complications: 12.8% vs 40.9%, p=0.002. Hospitalization
was infrequent among vaccinated patients (only 3 of 10
patients requiring hospital admission due to ILI were
vaccinated) and ILI lethality was 0%, whilst it was 4.5%
in unvaccinated patients. Among vaccinated patients,
those receiving adjuvated vaccines had lower incidence
of ILI (4.8% vs 9.9%, p=0.046). No difference has been
found between trivalent and quadrivalent vaccines
(p=0.09). Adverse events (AEs) to flu vaccine were rare
and mild (1.6%, grade 1-2).
Conclusions: The flu vaccine administration was not correlated with ILI incidence, but it significantly reduced ILI
complications, with no ILI-related deaths in vaccinated
patients. Influenza vaccination should be recommended in
ICI-treated cancer patients; adjuvated vaccines may be
preferred in this patient population.


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Tumori Journal Abstract Book - October 2020

Table of Contents for the Digital Edition of Tumori Journal Abstract Book - October 2020

Contents
Tumori Journal Abstract Book - October 2020 - Cover1
Tumori Journal Abstract Book - October 2020 - Cover2
Tumori Journal Abstract Book - October 2020 - I
Tumori Journal Abstract Book - October 2020 - II
Tumori Journal Abstract Book - October 2020 - Contents
Tumori Journal Abstract Book - October 2020 - IV
Tumori Journal Abstract Book - October 2020 - V
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