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´sume
´
Re
Ces dernie
`res anne
´es, des progre
`s e
´normes ont e
´te
´ re
´alise
´s dans notre capacite
´a
` caracte
´riser les communaute
´s microbiennes complexes telles que le microbiote intestinal (MI), et de nombreuses enque
ˆtes mene
´es
sur le MI ont identifie
´ un nombre incalculable d'associations entre diffe
´rents attributs de composition du MI et
les effets inde
´sirables sur la sante
´. Cependant, la majorite
´ de ces re
´sultats chez les humains sont purement
corre
´latifs et les mode
`les animaux sont ne
´cessaires a
` l'e
´valuation prospective de ces changements en tant
que facteurs e
´tiologiques de l'initiation ou de la progression de la maladie. Comme dans la plupart des
domaines de la recherche biome
´dicale, les e
´tudes axe
´es sur le microbiote sont principalement effectue
´es
sur des mode
`les de souris ou de rat. Selon le domaine de la recherche et la question ou l'objectif de
l'expe
´rience, des mode
`les autres que des rongeurs peuvent e
ˆtre pre
´fe
´rables en raison de meilleures possibilite
´s de translation ou du fait de l'impossibilite
´ d'utiliser des rongeurs pour diverses raisons. L'e
´tude ciapre
`s de
´crit l'utilite
´ et les limites de plusieurs mode
`les issus d'espe
`ces autres que les rongeurs pour la
recherche sur la sante
´quilibrer
´ humaine, et leur influence sur la physiologie de l'ho
ˆte et la maladie. Afin d'e
l'e
´tendue des espe
`ces de mode
`les potentiels avec la quantite
´ de de
´tails fournie, quatre espe
`ces de mode
`les
sont discute
´es : le poisson-ze
`bre, le chien, le porc et le lapin.

Abstract
In den letzten Jahren haben sich unsere Fa
¨higkeiten zur Charakterisierung komplexer mikrobieller
Gemeinschaften wie der Darmflora (intestinale Mikrobiota, GM) wesentlich verbessert, und bei zahlreichen
Untersuchungen der menschlichen GM wurden unza
¨hlige Zusammenha
¨nge zwischen verschiedenen
Merkmalen der Zusammensetzung der GM und ungu
¨ nstigen gesundheitlichen Umsta
¨nden erkannt. Die meisten dieser Ergebnisse beim Menschen sind jedoch rein korrelativ, und Tiermodelle sind fu
¨r die prospektive
Bewertung von solchen Vera
¨nderungen als ursa
¨chliche Faktoren bei der Entstehung oder dem Fortschreiten
von Krankheiten erforderlich. Wie in den meisten Bereichen der biomedizinischen Forschung werden
Mikrobiota-Studien u
¨ berwiegend mit Maus- oder Rattenmodellen durchgefu
¨ hrt. Je nach Forschungsgebiet



Laboratory Animals - June Issue

Table of Contents for the Digital Edition of Laboratory Animals - June Issue

Contents
Laboratory Animals - June Issue - Cover1
Laboratory Animals - June Issue - Cover2
Laboratory Animals - June Issue - Contents
Laboratory Animals - June Issue - 214
Laboratory Animals - June Issue - 215
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Laboratory Animals - June Issue - Cover3
Laboratory Animals - June Issue - Cover4
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