Laboratory Animals - June Issue - 251

Lundberg

251

re
´duire ces limites, mais une e
´valuation minutieuse des avantages, des inconve
´nients et des alternatives
possibles reste encore ne
´cessaire.

Abstract
Die mit menschlicher Darmmikrobiota besiedelte Maus stellt ein interessantes Modellkonzept mit Vor- und
Nachteilen wie jedes andere Modellsystem dar. Das Konzept bietet einen o
¨kologisch relevanten Kontext fu
¨r
die Untersuchung des Metabolismus von Nahrungsmittelbestandteilen und Arzneimitteln und ist ein wertvolles Instrument fu
¨ r Pha
¨notyp-Transferstudien, um die Rolle der Darmmikrobiota bei Gesundheit und
¨ bertragung bestimmter
Krankheit nachzuweisen. Die gro
¨ßten Nachteile sind die Schwierigkeiten bei der U
Bestandteile der menschlichen Mikrobiota auf die Empfa
¨ngerma
¨use und die bei diesen Ma
¨usen beobachteten
immunologischen Anomalien. Es scheint unerforschte Mo
¨glichkeiten zu geben, diese Einschra
¨nkungen zu
reduzieren, aber eine sorgfa
¨ltige Bewertung von Vor- und Nachteilen und mo
¨glichen Alternativen muss
weiterhin erfolgen.

Resumen
El rato
´n colonizado por microbiota fecal humana es un concepto de modelo interesante con ventajas y
desventajas como cualquier otro sistema modelo. El concepto proporciona un contexto ecolo
´gicamente
relevante para estudiar los componentes de los alimentos y el metabolismo de los fa
´rmacos, y es una
herramienta invaluable para los estudios de transferencia de fenotipos para demostrar el papel de la microbiota intestinal en la salud y la enfermedad. Los principales inconvenientes son las dificultades con la
transferencia de ciertos componentes de la microbiota humana a los ratones receptores y las anomalı´as
inmunolo
´gicas observadas en estos ratones. Parece haber oportunidades inexploradas para intentar reducir
estas limitaciones, pero au
´n es necesaria una evaluacio
´n cuidadosa de las ventajas, desventajas y las posibles
alternativas.



Laboratory Animals - June Issue

Table of Contents for the Digital Edition of Laboratory Animals - June Issue

Contents
Laboratory Animals - June Issue - Cover1
Laboratory Animals - June Issue - Cover2
Laboratory Animals - June Issue - Contents
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Laboratory Animals - June Issue - Cover3
Laboratory Animals - June Issue - Cover4
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