JCU - Abstracts of the BAUS 2018 Scientific Meeting - June 2018 - 75

Abstracts
Results: Mean age was 34 years (range 17-76). Of the 90
specimens from TSS, 54 were benign and 36 were malignant on FSA. Mean tumour size on US was 9.13mm (1.933.0) for benign lesions and 13.2mm (3.7-44.0) for
malignant lesions. 47 (87.0%) of the benign lesions, were
managed with TSS only, and 7 (13.0%) underwent delayed
IO. Of the 36 malignancies, 17 (47.2%) were managed with
TSS only, in patients with a solitary testis, bilateral tumours
or those refusing IO. 19 (52.8%) malignancies were managed with an additional IO. There was recurrence of 4
(23.5%) malignancies managed by TSS alone. Mean time to
recurrence was 31 months (range 2-72 months). All recurrences were safely managed by further surgery. Overall,
the testis-sparing rate was 87% for benign pathologies and
38.9% for malignancies.
Conclusions: TSS is an effective treatment option for
benign lesions. It may also be offered to manage testicular
cancers in selected cases; however, a vigorous post-operative US programme must be followed due to the relatively
high rates of recurrence.
P9-3 A comparison of robotic and open
retroperitoneal lymph node dissection in a
centralised single surgeon post-chemotherapy
surgical practice
Johnston T1, Lee E1, Coret M1, Adshead J1, Baldwin P1,
Klatte T1, Riddick A1, Thomas B1
1Addenbrooke's Hospital, Cambridge, United Kingdom

Aims: To compare the outcomes of patients undergoing
robotic retroperitoneal lymph node dissection (RPLND)
to patients who had an open RPLND in a predominantly
post-chemotherapy single surgeon surgical practice.
Methods: We compared the peri-operative and pathological outcomes of all patients undergoing post- chemotherapy open RPLND (55 patients) and robotic RPLND (10
patients) by a single surgeon. A matched pair analysis of
patients who had an open RPLND (20 patients) for the
same inclusion criteria for robotic RPLND was performed.
Results: 65 of 67 patients had a post-chemotherapy
RPLND.Ten patients had a robotic RPLND and 55 patients
had an open RPLND. There were significant differences in
median operative duration (150 vs 240 minutes p<0.0001),
estimated blood loss (50 vs 1000mls, p<0.0001) and length
of stay (1 vs 6 days, p<0.0001) in favour of robotic RPLND.
There were no conversions in the robotic RPLND group.
A matched pair analysis of 20 patients who had an open
RPLND showed median operative duration (153 vs 195
minutes, p<0.0001), estimated blood loss (50 vs 400mls,
p=0.03) and length of stay (1 vs 5 days, p<0.0001) were all
reduced in patients having robotic RPLND.
One patient in the robotic RPLND group and two patients
in the open RPLND group had chylous ascites requiring
percutaneous drainage and dietary modification.

75
Conclusion: Robotic RPLND may have a role in selected
patients with retroperitoneal disease, including in the
post-chemotherapy setting. There are potential benefits
with operative duration, length of stay and blood loss with
the robotic approach.
P9-4 9p chromosomal deletion on arraybased copy number analysis predicts
recurrence in non-metastatic clear cell renal
cell carcinoma (ccRCC) following surgical
resection
Quddus B, El-Mokadem I, Fleming S, Pratt N, Nabi G1
1Ninewells Hospital, Dundee, United Kingdom

Background: Copy number variations (CNVs) affect
biological and clinical behaviour of cancers. The aim of this
study was to assess CNVs in tumour tissue of a historic
group of patients with clear cell RCC.
Methods: 38 consecutive ccRCC cases with median follow up of 81.5 months were identified from Tayside Tissue
Bank archive. Histology was confirmed by specialist uropathologist. DNA extracted from Fresh frozen samples in
33 cases was analysed with CytoChipOligo™ BlueGenome
(Illumina®). Affymetrix OncoScan® FFPE assay was
employed to analyse highly degraded DNA extracted
from 5 FFPE samples. Nexus software (Biodiscovery®)
version 7.5 was used to analyse array based data. Coxproportional hazard survival analysis for recurrence-free
survival (RFS) was performed.
Results: Mean age of cohort was 65 years. Loss of 3p was
detected in 95% of the tumours. Other common chromosomal CNVs detected were deletions of 4q (34%), 9p
(34%), 14q (34%) and 18q (34%). Common gains included
5q (50%) and 7q (23%). Only 9p deletion was associated
with high grade tumours. Ten out of 32 cases with localised ccRCC at diagnosis developed recurrence, with a
median follow up of 86.5 months. Out of all clinico-pathological and CNVs, somatic deletion of chromosome 9p
was the only significant predictor of recurrence (p=0.002;
Hazard ratio: 8.8).
Conclusion: The study confirms that 9p deletion is one
of the most common CNVs in ccRCC. Moreover, this is
the first array based analysis study, with follow up exceeding 7 years, showing that 9p deletion is associated with
higher of recurrence in non-metastatic ccRCC.
P9-5 Change in nephrometry scoring in small
renal masses (<4cm) on active surveillance:
observations from tayside active surveillance
cohort (TASC) study
Zang W, Paterson C, Lang S, Szewczyk-Bieda M,
Nabi G1
1Ninewells Hospital, Dundee, United Kingdom



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