JCU - Abstracts of the BAUS 2018 Scientific Meeting - June 2018 - 63

Abstracts
are eligible. tE2 is delivered as 100mcg/24hr oestradiol patches;
LHRHa administered as per local practice. The Independent
Data Monitoring Committee has permitted release of the
CVS morbidity and mortality data. Treatment effect on CVS
risk was estimated using Cox models, stratified by recruitment before/after allocation ratio change.
Results: 1127 (621 tE2, 506 LHRHa) men recruited
between 14/08/07 and 21/11/16. Baseline characteristics
were similar between groups; overall median age 74 (IQR
68-79) years, PSA 39 (17-106) ng/mL, 40% metastatic disease, 59% current/previous smokers. Median follow-up
was 3.2 (IQR 0.9-5.1) years. At 3 months, 94.0% of tE2
group and 93.8% LHRHa had testosterone concentrations
d1.7 nmol/L. 100 CVS events were reported, 60 in 57
(9.2%) tE2 patients and 40 in 36 (7.1%) LHRHa; hazard
ratio comparing tE2 vs LHRHa 1.19 (95%CI 0.78-1.81,
P=0.432). 18/60 (30%) CVS events in tE2 group occurred
>6 months after patients stopped treatment with tE2.
Conclusions: Rates of CVS toxicity were similar between
tE2 and LHRHa. A tE2 arm was recently added to the
STAMPEDE trial platform to speed up the efficacy evaluation on prostate cancer outcomes.
P6-15 Prospective pilot study of patientreported fatigue, physical activity and
cardiovascular status in men after roboticassisted radical prostatectomy
Ashton R1, Tew G1, Saxton J1, Aning J2
University, Newcastle Upon Tyne, United Kingdom,
2Department of Urology, Freeman Hospital, Newcastle Upon Tyne,
United Kingdom
1Northumbria

63
Introduction: Patient-reported fatigue after roboticassisted radical prostatectomy (RARP) has not been characterised to date. It is commonly assumed that men
undergoing RARP are active, fit and return to their preoperative status after surgery. Fatigue after other prostate
cancer treatments significantly impact on patient-reported
quality of life. The aim of this pilot study was to investigate
fatigue, physical activity (PA) levels and cardiovascular status in men after RARP.
Patients and Methods: Between October 2016 and
March 2017, consecutive men post-RARP or on androgen
deprivation therapy (ADT) attending a weekly urology
clinic in a RARP centre were invited to participate in the
study (NHS REC South Scotland). Men were given the
Brief Fatigue Inventory, Stage of Change and Scottish
Physical Activity Questionnaires to complete over a twoweek period and return in a prepaid stamp addressed
envelope. Data were analysed using IBM SPSS Statistics.
Results: In total 96/117 (82%) men approached consented
and 62/96 (65%) returned complete questionnaire data.
Table 1 summarises the results. The cohort of men who
underwent RARP were overweight and had an 18.1% risk
of suffering a heart attack within the next 10 years.Although
all patients undergoing RARP reported fatigue, 9/42 patients
post-RARP reported clinically significant fatigue. Patientreported PA mainly consisted of walking (51.3%).
Conclusions: A significant proportion of men experience
fatigue, are physically inactive and at risk of developing cardiovascular disease after RARP. Our pilot study indicates
that a larger cross-sectional study of men after RARP is
warranted. These men would benefit from a structured
interventions to improve health after RARP.

P6-15: Table 1. Participant characteristics of the two treatment groups.

Months since treatment mean (range)
Age (years)
Body Mass Index (kg/m2)
QRISK (%)
Stage of change (number of patients)
Stage 1 - Pre-contemplation
Stage 2 - Contemplation
Stage 3 - Preparation
Stage 4 - Action
Stage 5 - Maintenance
SPAQ Total (mins)
Walking (% of total mins)
Manual Labour (% of total mins)
Active Housework (% of total mins)
Dancing (% of total mins)
Sport/Leisure Activities (% of total mins)
Other (% of total mins)
Brief Fatigue Inventory

RARP
(n = 42)

ADT (Control group)
(n = 20)

11.7 (2-115)
63.8 ± 6.4
27.0 ± 3.9
18.1

22.1 (2-120)
67.3 ± 9.0
27.8 ± 3.1
22.4

0
1
0
5
36
658 ± 337.6
51.7
19
8.7
0.5
14.0
6.1
1.6 ± 1.7

0
3
1
3
13
631.9 ± 318.5
50.9
14.7
13.1
0.1
20.1
1.0
2.5 ± 1.8

Data are presented as mean ± standard deviation unless stated otherwise. Brief fatigue Inventory presented as a global score over a two week period (range
of scores reported 1-6). SPAQ - Scottish physical activity questionnaire. QRISK - the risk of developing cardiovascular disease over the next 10 years.



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