JCU - Abstracts of the BAUS 2018 Scientific Meeting - June 2018 - 21

Abstracts

21

have CPET when undergoing MIS (robotic/laparoscopic)
compared to an open surgical approach. Planned admissions to HDU were higher in patients who underwent
CPET (81%, 71% respectively), with no differences in
unplanned admissions or between high/low risk groups.
Length of stay (LOS) varied across the groups (Table 1).
Patients undergoing CPET and open RC had higher rates
of post-operative complications particularly if high risk
(principally wound infection and prolonged ileus) with no
differences in MIS. No differences in complications
between high and low risk groups.
CPET was performed in 1 in 4 patients undergoing RC. It
is more commonly used in centres offering MIS.AT threshold doesn't seem to be associated with post-operative
complication rates. LOS varied with surgical approach and
CPET category - shortest LOS in low risk MIS group.
30/90-day mortality rates were low in all groups.
P1-16: Table 1
CPET

High
Low

NO CPET

OPEN

MIS

OPEN

MIS

13.6
15.3

12.7
9.1

14.4

10.3

P1-17 British Association of Urological
Surgeons (BAUS) cystectomy database
2015-2016: the impact of pre-operative renal
failure (RF) and / or hydronephrosis on the
outcome of radical cystectomy (RC) on behalf
of the BAUS section of oncology
M1,

recorded in 905 (99.7% with an eGFR <60), 91% CKD 3
9% CKD 4/5. Patients with RF tended to be older but
other demographics were comparable. Upper tract status
(UTS) was recorded in 85% of patients; 15% (n=518) unilateral hydronephrosis, 6% (n=208) bilateral hydronephrosis. Of those with CKD 3 50% had normal UTS, worsening
degrees of RF were associated with increasing hydronephrosis (Figure 1). RF and hydronephrosis were associated
with advanced tumour stage, open rather than minimally
invasive surgery (MIS) and increased intra-operative complications. Length of stay (LOS) was higher. 30/90-d mortality varied across the groups but prone to small sample
size effect.
Conclusion: Approximately 1 in 4 patients undergoing
RC had impaired renal function. 22% had HN. Despite
small sample size, there is an association between worsening renal function and worsening UTS. RF +/- hydronephrosis is associated with advanced tumour stage, increased
intra-operative complications and increased LOS.

E2,

J3,

P1-17: Figure 1

S4,

Moore
Rowe
Cresswell
Fowler
McGrath J1
1Royal Devon and Exeter NHS Foundation Trust, Exeter, United
Kingdom, 2North Bristol NHS Trust, United Kingdom, 3James
Cook University Hospital, Middlesbrough, United Kingdom, 4British
Association of Urological Surgeons, London, United Kingdom

Introduction and Objectives: Published data suggests
>50% of patients undergoing RC have prior RF +/- hydronephrosis and this may be a surrogate marker for poor
clinical outcomes.
Materials and Methods: Data from 2015/2016 were
extracted from BAUS audit dataset. 3964 patients underwent RC. CKD categories were used to stratify patients:
CKD 1/2 GFR (60->90mL/min), 3a/3b (30-59), 4 (16-29)
and 5 (<15). Hydronephrosis was recorded absent, unilateral or bilateral. Demographics, surgical factors and
outcomes (LOS, complications, 30/90-d mortality) were
compared.
Results: eGFR was recorded as >60 (72%) or <60 (28%)
in 85% of patients (n=3372). Exact eGFR figures were

P1-18 The utility of plasma cell-free DNA
mutations in detecting metastatic recurrence
in patients after radical cystectomy for
bladder cancer
Khetrapal P1, Dong L2, Wong Y2, Tan W1, Rodney S1,
Lamb B1, Briggs T1, Thompson J1, Sridhar A1, Kelly J1,
Feber A1
1University College Hospital Urology Department, London, United
Kingdom, 2UCL Cancer Institute, London, United Kingdom

Introduction and Objective: In routine practice, imaging is used for surveillance of metastatic bladder cancer
for patients after radical cystectomy (RC). With the availability of high-throughput sequencing, there is a growing
interest in utilising non-invasive liquid biopsy biomarkers
to supplement imaging in detecting metastatic disease.
Methods: 80 patients undergoing RC were prospectively
recruited under the UCL/UCLH Biobank for Studying
Health and Disease (Ethics approval (NC06.11) (HTA



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