JCU - Abstracts of the BAUS 2018 Scientific Meeting - June 2018 - 11

Abstracts

11

Best Academic Paper 2: Table 1. Mixed Effects Multivariable Model with outcome SSP.
Variable

Odds ratio estimate (95% confidence interval)

Age (years)
Gender: Male
MET administered: YES
Stone location: Middle ureter
Stone location: Upper ureter
MET Administered: Stone position: Middle ureter
MET Administered: Stone position: Upper ureter
Stone size (mm)
MET Administered * Stone size (mm) - interaction term

1.006 (1.000, 1.012)
0.869 (0.712, 1.061)
0.861 (0.521, 1.424)
0.806 (0.546, 1.189)
0.435 (0.332, 0.569)
0.808 (0.458, 1.424)
1.086 (0.716, 1.645)
0.714 (0.666, 0.767)
1.085 (0.978, 1.205)
Estimate (95% confidence interval)
0.268 (0.160, 0.449)

Random Effect Variance

3 - A Genome-wide association study
of kidney stone disease reveals 5 novel
susceptibility loci
Howles S1, Wiberg A2, Furness D2, Turney B1
Department of Surgical Sciences, University of Oxford,
Oxford, United Kingdom, 2Nuffield Department of Orthopaedics,
Rheumatology and Musculoskeletal Sciences, University of Oxford,
Oxford, United Kingdom
1Nuffield

Introduction: Kidney stone disease is a major clinical
and economic health burden with a multifactorial aetiology and a heritability of 56%. We undertook the largest
genome-wide association study to date using data from
the UK Biobank to identify novel genetic factors contributing to nephrolithiasis.
Methods: ICD-10 and OPCS codes were used to identify individuals with a history of nephrolithiasis and to
exclude those with disorders of calcium homeostasis,
malabsorption and conditions associated with kidney
stone disease. All other individuals were used as
controls.
Results: A total of 6537 nephrolithiasis cases and
388,509 controls were identified. Nine loci with multiple
SNPs achieving GWAS significance of p<5×10-࢞ were
identified. Of these, 5 loci were novel: DGKD region on
chromosome 2q37.1 encoding the second messenger
diacylglycerol kinase delta, SLC22A1-SLC22A2-IGF2R
on chromosome 6q25.3 encoding cation transporters
and the insulin like growth factor 2 receptor, HIBADH
region on chromosome 7p15.2 encoding 3-hydroxyisobutyrate dehydrogenase which has a role in urinary
acidification, CYP24A1 region on chromosome 20q13.2
encoding cytochrome P450 family 24 subfamily A1 which
inactivates 1,25-dihydroxyvitamin D, and GNAZRSPH14 region on chromosome 22q.11.23 encoding
G-protein subunit Dz and radial spoke head 14 homolog,

a protein with an undefined function. As previously
reported ALPL, RGS14, DGKH and CLDN14 regions
were also found to be associated with kidney stone
disease.
Conclusion: These results reveal novel susceptibility loci
for nephrolithiasis opening up new avenues of research
into the pathophysiology of this poorly understood disorder. This will facilitate development of novel treatments
for those suffering from kidney stone disease.
4 - Optimal surgical treatment of T1 renal
tumours correlates with nephrectomy
volume
Tran M1,2, Aben K3, Neves J1, Fowler S5,
Sullivan M7, Stewart G6, Challacombe B8,
Mahrous A2, Patki P2, Mumtaz F2, Barod R2,
Aitchison M2, Bex A2,4
1UCL Division of Surgery and Interventional Science, London, United
Kingdom, 2Specialist Center for Kidney Cancer, Royal Free Hospital,
London, United Kingdom, 3Netherlands Comprehensive Cancer
Center, Netherlands, 4Netherlands Cancer Institute, Netherlands,
5BAUS, UK, 6Cambridge University Hospitals, Addenbrookes
Hospital, Cambridge, UK, 7Oxford University Hospitals, Churchill
Hospital, Oxford, UK, 8Guy's Hospital and King College London,
London, UK

Introduction: EAU renal cancer guidelines recommend
partial nephrectomy (PN) in patients with T1 tumours
whenever feasible. The aim of this study was to evaluate
surgical management of T1 tumours across the nation to
assess EAU guideline adherence and the effects of centralization of care.
Patients and Methods: BAUS nephrectomy audit data
from all T1 tumours that underwent radical nephrectomy
(RN) or PN in the period 2012-2016 were analysed. We
assessed: total surgical volume (RN and PN performed)



Table of Contents for the Digital Edition of JCU - Abstracts of the BAUS 2018 Scientific Meeting - June 2018

Contents
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