ESC Congress 2016 - 33

Your FREE access to ESC Congress content all year long www.escardio.org/365 The primary endpoint was time to first occurrence of all-cause death, any ischemic event leading to hospitalization, or evidence of organ failure (heart failure, cognitive dysfunction, renal dysfunction, atrial or ventricular arrhythmia, malignant hypertension). The main secondary endpoint was a composite of all-cause death, MI, stroke, and any revascularization. The main safety endpoint was TIMI major bleeding. At 2-year follow-up, there was no significant difference in the primary endpoint rate between the proactive (47.4%) and conventional (46.9%) arms (HR, 1.03; 95% CI, 0.80 to 1.34). No significant difference in the secondary endpoint rate was observed between the proactive (13.9%) and conventional (15.0%) arms (HR, 0.94; 95% CI, 0.58 to 1.50). There were no significant differences in the proactive vs conventional arms in any of the main secondary outcomes, including all-cause mortality; critical limb ischemia; revascularization; percutaneous coronary intervention or coronary artery bypass grafting surgery and organ failure (P = NS for all) A prespecified subgroup analysis showed no significant differences in primary endpoint rates between the arms in any subgroups. No significant difference was observed between the arms in major TIMI bleeding (P = .73). Asymptomatic MSAD was identified in 1 out of 5 patients with CAD that qualified for this study. Routine screening did not appear to improve a broad array of outcomes in this modestly sized study. The results do not support routine screening for asymptomatic multisite vascular disease in patients who are already identified as high risk due to recent ACS or multivessel coronary disease and are already receiving secondary prevention therapy. ESC CONGRESS 2016 IN REVIEW The editors would like to thank the many members of the ESC Congress 2016 presenting faculty who generously gave their time to ensure the accuracy and quality of the articles in this publication Official Peer-Reviewed Highlights From ESC Congress 2016 33 http://www.escardio.org/365

Table of Contents for the Digital Edition of ESC Congress 2016