At Home with Chris Jessen 2018 - 44
WINNING THE WAR?
A 2014 WHO report warned that the
world was entering a 'post-antibiotic
era', with potentially catastrophic
implications. However, scientists are
working hard to come up with ways
to combat this threat.
A new type of antibiotic called
teixobactin has been developed that
has destroyed some drug-resistant
bacteria when tested on mice. It kills
microbes by blocking their capacity to
build their cell walls properly, making
it extremely difficult for the bacteria
to gain resistance. It works against
WITHOUT EFFECTIVE ANTIBIOTICS, EVEN
ROUTINE OPERATIONS, SUCH AS HIP
REPLACEMENTS, COULD BECOME HIGH-RISK
DR
CHRISTIAN
SAYS
'We all
need to
stop taking
antibiotics
unless it's
absolutely
necessary.
Don't ask
your GP for
them if you
have cold or
flu. If you do
need to take
them, finish
the course.'
044 | FEBRUARY 2018
bacteria that lack outer membranes,
known as 'gram-positive' bacteria,
such as MRSA and TB, but it doesn't
work against bacteria that have
outer membranes - 'gram-negative'
bacteria - including some of the
most worrying antibiotic-resistant
pathogens, such as E. coli, which
causes food poisoning. There is still
years' worth of work to be done before
teixobactin could be available.
Experts are also looking at the
potential of prebiotics to fight
infection, and there has been some
promising research. But while these
steps are in the right direction, if more
isn't done soon it will mean the huge
gains made since the discovery of
penicillin by Alexander Fleming back
in 1928, in curbing conditions such as
pneumonia and tuberculosis and in
making childbirth safer, will be lost.
THE CONSEQUENCES
Without effective antibiotics, even
minor surgery and routine operations,
such hip and knee replacements,
could become high-risk procedures,
leading to increased duration of illness
and ultimately premature mortality,
according to a recent National Risk
Register of Civil Emergencies report.
'Much of modern medicine, for
example organ transplantation, bowel
surgery and some cancer treatments,
may become unsafe due to the increased
risk of infection,' the report states.
It adds: 'The n umber of infections
complicated by anti-microbial
resistance are expected to increase
markedly over the next 20 years. If a
widespread outbreak was to occur, we
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